澳大利亚杀人蝎毒液中毒素的多态性和定量变化

Polymorphism and quantitative variations of toxins in the venom of the scorpion Androctonus australis Hector.

作者信息

el Ayeb M, Rochat H

出版信息

Toxicon. 1985;23(5):755-60. doi: 10.1016/0041-0101(85)90005-4.

Abstract

Using highly specific radioimmunoassays for toxins I, II and III of the scorpion Androctonus australis Hector, the concentrations of these neurotoxins have been determined in pooled as well as in individual samples. Variations were found that support polymorphism of scorpion toxins at an individual level. Radioimmunoassays were also used to detect toxin I of Buthus occitanus tunetanus and toxin II of Androctonus australis Hector and also antigenically homologous toxins in the venoms of several North African scorpions. These results are interpreted in terms of scorpion serotherapy.

摘要

利用针对澳毒蝎（Androctonus australis Hector）毒素I、II和III的高特异性放射免疫测定法，已测定了混合样本以及单个样本中这些神经毒素的浓度。发现的差异支持了蝎毒素在个体水平上的多态性。放射免疫测定法还用于检测北非蝎（Buthus occitanus tunetanus）的毒素I和澳毒蝎的毒素II，以及几种北非蝎毒液中的抗原同源毒素。这些结果从蝎毒血清疗法的角度进行了解释。