Mori S, Takeuchi Y, Toyama M, Makino S, Ohhara T, Tochino Y, Hayashi Y
Toxicol Lett. 1985 Dec;29(2-3):145-52. doi: 10.1016/0378-4274(85)90035-9.
Strain differences in the induction of hepatocellular preneoplastic lesions by amitrole were examined in NOD, ICR and DS mice. Amitrole was administered to mice in drinking water at a dose of 1% for 6 months. After 3 months, hyperplastic nodules (HN) and severe fibrosis were prominent in NOD mice but not in other strains. On examination at 6 months, both number and size of HN were greatest in the NOD strain. Furthermore, a hepatocellular carcinoma was found in a NOD mouse, suggesting that this strain is more susceptible to amitrole-induced hepatocarcinogenesis than are ICR or DS mice.
研究了在NOD、ICR和DS小鼠中，杀草强诱导肝细胞癌前病变的品系差异。以1%的剂量将杀草强添加到小鼠饮用水中，持续给药6个月。3个月后，NOD小鼠出现增生性结节（HN）和严重纤维化，而其他品系未出现。在6个月时检查发现，NOD品系中HN的数量和大小均最大。此外，在一只NOD小鼠中发现了肝细胞癌，这表明该品系比ICR或DS小鼠更易受到杀草强诱导的肝癌发生作用。
