Lázaro Iolanda, Luján-Barroso Leila, Soldevila-Domenech Natalia, Amor Antonio J, Ortega Emilio, Ros Emilio, Sánchez Maria-José, Rodríguez-Barranco Miguel, Chirlaque Maria Dolores, Huerta José Maria, Guevara Marcela, Moreno-Iribas Conchi, Bonet Catalina, Schröder Helmut, Fitó Montserrat, Tintle Nathan L, Ryder Nathan, Harris William S, Agudo Antonio, Sala-Vila Aleix
Hospital del Mar Medical Research Institute, Barcelona, Spain.
Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
Eur Stroke J. 2025 Sep 3:23969873251367250. doi: 10.1177/23969873251367250.
Poor-quality diets promote ischemic stroke. Red blood cell fatty acids (RBC-FAs) are objective, long-term biomarkers of diet. In a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain, we developed a blood-based lipidomic fat quality (LFQ) score considering pre-defined RBC-FA diet-related biomarkers, and examined whether LFQ score relates to the risk of ischemic stroke.
We determined the RBC-FAs ( = 438 cases of incident ischemic stroke, = 438 matched controls). For each participant, we scored 1 for each beneficial metric (C15:0+C17:0; C18:2n-6; C18:3n-3; C20:5n-3; C22:6n-3) ⩾the median of the control group; and 1 for each detrimental metric (C16:0; C16:1n-7; C18:0) = 2468 participants from the Framingham Offspring Study without ischemic stroke at baseline, 12-year median follow-up, = 121 cases).
In a fully adjusted model, the Odds Ratio (OR) for ischemic stroke was 0.86 (95% confidence interval [CI] = 0.77-0.95) for each 1-unit increase of the LFQ score. Compared to individuals at the lowest category of LFQ score (0-3 points), those at the top category (5-8 points) had lower odds (OR = 0.64, 95% CI = 0.44-0.94). The findings were similar in the Framingham Offspring Study (Hazard Ratio [HR] for each 1-unit increase = 0.83; 95% CI = 0.70-0.99; HR for those at top category = 0.49; 95% CI = 0.29-0.84, compared to those at the lowest category).
Low blood-based LFQ scores relate to a high risk of ischemic stroke.
低质量饮食会增加缺血性中风的风险。红细胞脂肪酸（RBC-FAs）是饮食的客观、长期生物标志物。在一项嵌套于欧洲癌症与营养前瞻性调查（EPIC）-西班牙研究中的病例对照研究中，我们根据预先定义的与饮食相关的RBC-FA生物标志物，制定了基于血液的脂质组脂肪质量（LFQ）评分，并研究了LFQ评分是否与缺血性中风风险相关。
我们测定了RBC-FAs（438例缺血性中风新发病例，438例匹配对照）。对于每位参与者，若每项有益指标（C15:0+C17:0；C18:2n-6；C18:3n-3；C20:5n-3；C22:6n-3）≥对照组中位数，则得1分；若每项有害指标（C16:0；C16:1n-7；C18:0）≥对照组中位数，则得-1分。计算每位参与者的LFQ评分。我们纳入了来自弗雷明汉后代研究的2468名基线时无缺血性中风的参与者，进行了12年的中位随访（121例病例）。
在完全调整模型中，LFQ评分每增加1个单位，缺血性中风的比值比（OR）为0.86（95%置信区间[CI]=0.77-0.95）。与LFQ评分最低类别（0-3分）的个体相比，最高类别（5-8分）的个体患缺血性中风的几率较低（OR=0.64，95%CI=0.44-0.94）。在弗雷明汉后代研究中也得到了类似的结果（每增加1个单位的风险比[HR]=0.83；95%CI=0.70-0.99；与最低类别相比，最高类别个体的HR=0.49；95%CI=0.29-0.84）。
基于血液的低LFQ评分与缺血性中风的高风险相关。
