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在人类免疫缺陷病毒(HIV)感染背景下播散性感染被误诊为结节病

Disseminated Infection With in the Setting of HIV Infection Misdiagnosed as Sarcoidosis.

作者信息

Eskandari Alireza, Rezaei Mitra, Shabani Minoosh, Pourabdoullah Mihan, Moniri Afshin, Marjani Majid

机构信息

Genomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Case Rep Infect Dis. 2025 Aug 24;2025:2249985. doi: 10.1155/crdi/2249985. eCollection 2025.

Abstract

was first identified in a patient with HIV. Here, we describe a 40-year-old man with prolonged fever and mediastinal and abdominal lymphadenopathy, who was initially misdiagnosed with sarcoidosis. A molecular study was conducted after mycobacterium was isolated from a lymph node biopsy, leading to the identification of . The identification of this microbe, along with recurrent oral candidiasis and varicella skin lesions, raised suspicion of an immunodeficiency disorder, which ultimately resulted in an HIV diagnosis. Concurrently, the patient experienced polyradiculopathy caused by cytomegalovirus. This case highlights that after identifying a granuloma in tissue, a comprehensive investigation to exclude infectious causes using microbiological and molecular methods is crucial.

摘要

最初在一名艾滋病患者中被发现。在此,我们描述一名40岁男性,有长期发热以及纵隔和腹部淋巴结病,最初被误诊为结节病。从淋巴结活检中分离出分枝杆菌后进行了分子研究,从而鉴定出……这种微生物的鉴定,连同复发性口腔念珠菌病和水痘皮肤病变,引发了对免疫缺陷疾病的怀疑,最终确诊为艾滋病。同时,该患者出现了由巨细胞病毒引起的多发性神经根病。这个病例强调,在组织中发现肉芽肿后,使用微生物学和分子方法进行全面调查以排除感染原因至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18cb/12399350/6ff247ce3420/CRIID2025-2249985.001.jpg

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