Institute of Food Science and Nutrition, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, 812 37 Bratislava, Slovakia.
Toxins (Basel). 2022 May 29;14(6):379. doi: 10.3390/toxins14060379.
Approximately one-third of humankind is chronically exposed to the carcinogenic aflatoxin M contained in milk. As β-cyclodextrin is frequently used in the food industry, its effect on aflatoxin M concentration was investigated during cholesterol removal from milk due to the similarity among the physicochemical properties of aflatoxin M and cholesterol. Moreover, the elimination of cholesterol using β-cyclodextrin has been successfully applied in many studies without any substantial effect on the quality of the treated milk. Therefore, milk samples were spiked with aflatoxin M within the range from 0.20 to 2.00 µg/kg, and cholesterol removal was carried out by 2.0% () β-cyclodextrin addition, as this concentration is enough for the sufficient removal of cholesterol. It was found that the mean cholesterol concentration decreased by 92.3%, while the aflatoxin M concentration decreased to 0.53 ± 0.04 µg/kg, i.e., by 39.1% after treatment (n = 2). This mitigation procedure itself is easy and inexpensive and thus is fully applicable with a high potential for complete decontamination of aflatoxin M milk. This method will therefore considerably improve the food safety issues associated with aflatoxin M presence in milk and dairy products.
约三分之一的人类会长期摄入含于奶中的致癌物质黄曲霉毒素 M。由于β-环糊精在食品工业中经常被使用，且黄曲霉毒素 M 和胆固醇的理化性质相似，所以在从奶中去除胆固醇的过程中，研究了其对黄曲霉毒素 M 浓度的影响。此外，使用β-环糊精去除胆固醇已在许多研究中成功应用，而对处理奶的质量没有任何实质性影响。因此，在 0.20 至 2.00 µg/kg 的范围内向奶样中添加黄曲霉毒素 M，并通过添加 2.0%（）β-环糊精来去除胆固醇，因为这种浓度足以充分去除胆固醇。结果发现，胆固醇浓度平均降低了 92.3%，而黄曲霉毒素 M 的浓度降低至 0.53 ± 0.04 µg/kg，即处理后降低了 39.1%（n = 2）。这种缓解过程本身简单且廉价，因此完全适用于黄曲霉毒素 M 奶的完全去污，具有很高的潜力。该方法将极大地改善与奶和奶制品中存在黄曲霉毒素 M 相关的食品安全问题。
