• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对（L.）A. Chev.叶提取物中生物活性化合物的鉴定及其对致龋微生物的抗菌活性。

Identification of bioactive compounds in (L.) A. Chev. leaf extract and its antimicrobial activity against cariogenic microorganisms.

作者信息

Alphianti Likky Tiara, Bachtiar Endang Winiati, Suniarti Dewi Fatma, Fauziah Eva

机构信息

Oral Science Research Centre, Faculty of Dentistry, Universitas Indonesia.

Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia and Oral Science Research Centre, Faculty of Dentistry, Universitas Indonesia.

出版信息

J Adv Pharm Technol Res. 2025 Jul-Sep;16(3):156-162. doi: 10.4103/JAPTR.JAPTR_76_25. Epub 2025 Aug 9.

DOI:10.4103/JAPTR.JAPTR_76_25
PMID:40901441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12401519/
Abstract

is an ornamental plant known for its therapeutic properties, particularly its antimicrobial activity. This study attempted to identify bioactive compounds in the leaf extract and assess their antibacterial and antifungal efficacy against and , which are key contributors to early childhood caries (ECC). leaves were extracted using the maceration technique with 70% methanol. Phytochemical and gas chromatography-mass spectrometry (GC-MS) screening were performed to identify secondary metabolites and chemical compounds. and were isolated from supragingival plaque samples of paediatric patients with severe ECC. The minimum inhibitory concentration (MIC) was determined through serial dilution and ELISA spectrophotometry. Phytochemical screening verified the existence of phenolic compounds, flavonoids, saponins, triterpenoids, and alkaloids. GC-MS identified 17 chemical compounds. The MIC was 6.25% for and 1.56% for . The extract exhibited significant antimicrobial activity, with a stronger inhibitory effect against than . The leaf extract demonstrates antibacterial and antifungal potential and may serve as a cariogenic antimicrobial agent. Further toxicological studies are needed to confirm its safety for clinical applications.

摘要

是一种因其治疗特性，特别是抗菌活性而闻名的观赏植物。本研究试图鉴定该植物叶提取物中的生物活性化合物，并评估它们对变形链球菌和远缘链球菌的抗菌和抗真菌功效，这两种菌是幼儿龋齿（ECC）的主要促成因素。采用浸渍技术用70%甲醇提取该植物的叶子。进行了植物化学和气相色谱 - 质谱（GC - MS）筛选以鉴定次生代谢物和化合物。从患有严重ECC的儿科患者的龈上菌斑样本中分离出变形链球菌和远缘链球菌。通过系列稀释和ELISA分光光度法测定最低抑菌浓度（MIC）。植物化学筛选证实了酚类化合物、黄酮类、皂苷、三萜类和生物碱的存在。GC - MS鉴定出17种化合物。变形链球菌的MIC为6.25%，远缘链球菌的MIC为1.56%。该提取物表现出显著的抗菌活性，对变形链球菌的抑制作用比对远缘链球菌更强。该植物叶提取物显示出抗菌和抗真菌潜力，可作为致龋抗菌剂。需要进一步的毒理学研究来确认其临床应用的安全性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc5/12401519/2d8d6e38a15e/JAPTR-16-156-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc5/12401519/92c0a805ed3d/JAPTR-16-156-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc5/12401519/10d084b5f212/JAPTR-16-156-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc5/12401519/2d8d6e38a15e/JAPTR-16-156-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc5/12401519/92c0a805ed3d/JAPTR-16-156-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc5/12401519/10d084b5f212/JAPTR-16-156-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0dc5/12401519/2d8d6e38a15e/JAPTR-16-156-g003.jpg

相似文献

1
Identification of bioactive compounds in (L.) A. Chev. leaf extract and its antimicrobial activity against cariogenic microorganisms.对（L.）A. Chev.叶提取物中生物活性化合物的鉴定及其对致龋微生物的抗菌活性。
J Adv Pharm Technol Res. 2025 Jul-Sep;16(3):156-162. doi: 10.4103/JAPTR.JAPTR_76_25. Epub 2025 Aug 9.
2
Standardization of extraction, identification, and characterization of an immunoglobulin Y antibody: A potential inhibitor of cariogenic and endodontic microbiome.免疫球蛋白Y抗体的提取、鉴定和表征的标准化：一种潜在的致龋和牙髓微生物群抑制剂。
J Conserv Dent Endod. 2025 Aug;28(8):772-782. doi: 10.4103/JCDE.JCDE_185_25. Epub 2025 Aug 1.
3
Effect of nanohydrogel-containing resin on and .含纳米水凝胶的树脂对……的影响
J Dent Res Dent Clin Dent Prospects. 2025 Jun 30;19(2):128-136. doi: 10.34172/joddd.025.41796. eCollection 2025 Jun.
4
Phytochemical profile and antimicrobial activity of individual frond extracts of Menisorus pauciflorus, Pteris catoptera, Conniogramme africana and Antrophyum mannianum.少花新月蕨、翅柄凤尾蕨、非洲凤了蕨和万年拟蕨单叶提取物的植物化学特征及抗菌活性
BMC Complement Med Ther. 2025 Jul 12;25(1):262. doi: 10.1186/s12906-025-05003-9.
5
Birth Cohort Study Identifies as a Risk Factor for Dental Caries.出生队列研究确定[具体内容缺失]为龋齿的一个风险因素。
J Dent Res. 2025 Jun 26:220345251340040. doi: 10.1177/00220345251340040.
6
Antifungal efficacy of Eugenia uniflora leaves extract: In vitro and insilico investigations against Candida albicans, C. auris and C. glabrata.番樱桃叶提取物的抗真菌功效：针对白色念珠菌、耳念珠菌和光滑念珠菌的体外和计算机模拟研究
J Ethnopharmacol. 2025 Jun 21;352:120181. doi: 10.1016/j.jep.2025.120181.
7
Inhibitory effects of berberine against : an insight on its anticaries potential.黄连素的抑制作用：对其防龋潜力的见解
Microbiol Spectr. 2025 Aug 12:e0070025. doi: 10.1128/spectrum.00700-25.
8
Potential clinical relevance of Buchholzia coriacea: in vitro antimicrobial characteristics of the methanol leaf extract.布氏厚皮树的潜在临床相关性：甲醇叶提取物的体外抗菌特性
BMC Complement Med Ther. 2025 Aug 19;25(1):309. doi: 10.1186/s12906-025-05057-9.
9
Green synthesis of gold nanoparticles using leaf extract: characterization and anti-microbial properties (An in-vitro study).利用树叶提取物绿色合成金纳米颗粒：表征及抗菌性能（一项体外研究）
F1000Res. 2024 Sep 2;13:572. doi: 10.12688/f1000research.150769.1. eCollection 2024.
10
Properties of Plant Extracts from Adriatic Maritime Zone for Innovative Food and Packaging Applications: Insights into Bioactive Profiles, Protective Effects, Antioxidant Potentials and Antimicrobial Activity.亚得里亚海沿海地区植物提取物在创新食品和包装应用中的特性：对生物活性特征、保护作用、抗氧化潜力和抗菌活性的见解。
Antioxidants (Basel). 2025 Jul 24;14(8):906. doi: 10.3390/antiox14080906.

本文引用的文献

1
GC/MS evaluation of the composition of the gel and extract.凝胶和提取物成分的气相色谱/质谱联用分析
Food Chem X. 2024 Jun 8;23:101536. doi: 10.1016/j.fochx.2024.101536. eCollection 2024 Oct 30.
2
Maltose accumulation-induced cell death in Saccharomyces cerevisiae.麦芽糖积累诱导酿酒酵母细胞死亡。
FEMS Yeast Res. 2024 Jan 9;24. doi: 10.1093/femsyr/foae012.
3
Ethnobotany, Phytochemistry, and Biological Activities of the Genus Cordyline.民族植物学、植物化学和 Cordyline 属的生物活性。
Biomolecules. 2023 Dec 12;13(12):1783. doi: 10.3390/biom13121783.
4
Effects of Harvest Timing on Phytochemical Composition in Plants under an Environment-Controlled System.收获时间对环境控制系统下植物中植物化学成分的影响。
Antioxidants (Basel). 2023 Oct 25;12(11):1909. doi: 10.3390/antiox12111909.
5
Anti- Effects and Mechanisms of Theasaponin E1 and Assamsaponin A.茶皂素 E1 和 Assamsaponin A 的抗作用和机制。
Int J Mol Sci. 2023 May 27;24(11):9350. doi: 10.3390/ijms24119350.
6
Carbonic Anhydrase Inhibitors as Novel Antibacterials in the Era of Antibiotic Resistance: Where Are We Now?碳酸酐酶抑制剂作为抗生素耐药时代的新型抗菌药物：我们目前的进展如何？
Antibiotics (Basel). 2023 Jan 10;12(1):142. doi: 10.3390/antibiotics12010142.
7
Comparison of the Antibacterial Activity and Effect on Membrane Permeability of Hibiscus Acid and a Commercial Chlorhexidine Mouthrinse Against Pathogenic Oral Bacteria and Determination of Hibiscus Acid Toxicity.比较芙蓉酸与一种商业化洗必泰漱口液对口腔致病菌的抗菌活性和对细胞膜通透性的影响，并测定芙蓉酸的毒性。
J Med Food. 2022 Mar;25(3):324-328. doi: 10.1089/jmf.2020.0207. Epub 2021 Dec 23.
8
Antifungal Activity of Novel Formulations Based on Terpenoid Prodrugs against in a Mouse Model.基于萜类前药的新型制剂在小鼠模型中对……的抗真菌活性 。 （原文中“against”后缺少具体对象）
Pharmaceutics. 2021 Apr 29;13(5):633. doi: 10.3390/pharmaceutics13050633.
9
Tetradecanoic Acids With Anti-Virulence Properties Increase the Pathogenicity of in a Murine Cutaneous Infection Model.具有抗毒力特性的十四烷酸在小鼠皮肤感染模型中增加了致病性。
Front Cell Infect Microbiol. 2021 Jan 27;10:597517. doi: 10.3389/fcimb.2020.597517. eCollection 2020.
10
Plant-derived isoquinoline alkaloids that target ergosterol biosynthesis discovered by using a novel antifungal screening tool.利用新型抗真菌筛选工具发现以麦角甾醇生物合成为靶点的植物源性异喹啉生物碱。
Biomed Pharmacother. 2021 May;137:111348. doi: 10.1016/j.biopha.2021.111348. Epub 2021 Feb 9.