Kanalli Prakruthi, Kundapur Rohan R, Joseph Manu M
Department of Life Sciences, CHRIST University Bengaluru - 560029 Karnataka India
RSC Adv. 2025 Sep 1;15(38):31162-31175. doi: 10.1039/d5ra03600c. eCollection 2025 Aug 29.
Clinical management of surgical site infections remains a challenge in biomedicine, where novel wound dressing materials are tested with a plethora of features. Here we describe a green and sustainable route to prepare biogenic zinc oxide nanoparticles (BZnONPs) using leaf extract, which acts as a green reducing and stabilising agent. These biosynthesised nanoparticles were then used for the functional coating of degummed silk fibers. Physico-chemical characterisation supports the efficient synthesis of crystalline, nanosized, and colloidal stable BZnONPs. The functionalization of silk fibers with BZnONPs resulted in the enhancement of the mechanical properties, tensile strength, and elasticity. Antibacterial testing proved the capability of the functional fibers against the strain . The as-synthesised fibers were biocompatible towards normal blood components, normal cells and exhibited slight toxicity toward cancer cells. Enhanced mechanical properties, antimicrobial action, and biocompatibility make BZnONP-coated silk fibers a leading player in various advanced biomedical devices, including sutures, wound dressings, tissue engineering scaffolds, and localised therapeutic platforms. Hence, this green nanotechnology approach opens up an alternative pathway toward the fabrication of multifunctional biomaterials with high translational value.
手术部位感染的临床管理在生物医学领域仍然是一项挑战，在该领域中，新型伤口敷料材料会进行大量特性测试。在此，我们描述了一种绿色可持续的方法，即使用树叶提取物制备生物源氧化锌纳米颗粒（BZnONPs），树叶提取物作为绿色还原剂和稳定剂。然后将这些生物合成的纳米颗粒用于脱胶丝纤维的功能涂层。物理化学表征支持了结晶、纳米尺寸且胶体稳定的BZnONPs的高效合成。用BZnONPs对丝纤维进行功能化处理可增强其机械性能、拉伸强度和弹性。抗菌测试证明了功能纤维对该菌株的抗菌能力。合成的纤维对正常血液成分、正常细胞具有生物相容性，对癌细胞表现出轻微毒性。增强的机械性能、抗菌作用和生物相容性使BZnONP涂层丝纤维在各种先进生物医学设备中占据主导地位，包括缝线、伤口敷料、组织工程支架和局部治疗平台。因此，这种绿色纳米技术方法为制造具有高转化价值的多功能生物材料开辟了一条替代途径。
