mA-driven transcriptomic rewiring in tumor immune surveillance.

RNA molecules are subject to extensive post-transcriptional modifications that fine-tune their stability, localization, and function. Among the more than 100 known RNA modifications, N6-methyladenosine (mA) is the most abundant internal mark on eukaryotic messenger RNAs. This dynamic modification is installed by methyltransferases ("writers"), removed by demethylases ("erasers"), and interpreted by RNA-binding proteins ("readers") to modulate gene expression. In this review, we examine the mechanisms governing mA deposition and its broad impact on mRNA fate. We then focus on the emerging roles of mA in shaping antitumor immune responses and discuss how targeting mA-regulated pathways can enhance the efficacy of existing immunotherapies. Finally, we highlight recent advances and ongoing challenges in the development of drugs that target key regulators of mA RNA modifications.