基于代谢组学的衰老时钟

Metabolomic-based aging clocks.

作者信息

Ibáñez de Opakua A, Conde R, de Diego A, Bizkarguenaga M, Embade N, Lu S C, Mato J M, Millet O

机构信息

ATLAS Molecular Pharma, Parque Tecnológico de Bizkaia, Ed. 800, 48160, Derio, Spain.

Precision Medicine and Metabolism Laboratory, CIC bioGUNE, Basque Research and Technology Alliance, Parque Tecnológico de Bizkaia, Ed. 800, 48160, Derio, Spain.

出版信息

NPJ Metab Health Dis. 2025 Sep 3;3(1):35. doi: 10.1038/s44324-025-00078-x.

DOI:10.1038/s44324-025-00078-x

PMID:40903544

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12408810/

Abstract

Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks. NMR-based metabolomic clocks provide a non-invasive, high-throughput platform to assess metabolic health. We summarize key NMR-based models and present a new approach that combines high predictive accuracy with clinical interpretability, identifying disease-specific metabolic distortions and supporting risk stratification and early detection of accelerated aging.

摘要

分子衰老时钟通过分子生物标志物来估计生物年龄，并且在预测健康结果方面往往优于实际年龄。其类型包括表观遗传时钟、转录组时钟、蛋白质组时钟和代谢组时钟。基于核磁共振的代谢组时钟提供了一个非侵入性的高通量平台来评估代谢健康状况。我们总结了基于核磁共振的关键模型，并提出了一种新方法，该方法将高预测准确性与临床可解释性相结合，识别特定疾病的代谢紊乱，支持风险分层以及加速衰老的早期检测。