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肛管恶性黑色素瘤:一例报告

Malignant melanoma of the anal canal: a case report.

作者信息

Parajuli Shubu, Sah Shruti, Pandit Narendra

机构信息

Department of GI Surgery, Birat Medical College and Teaching Hospital, Tankisinwari, Morang, Biratnagar 56613, Nepal.

出版信息

J Surg Case Rep. 2025 Sep 2;2025(9):rjaf700. doi: 10.1093/jscr/rjaf700. eCollection 2025 Sep.

Abstract

Anal melanoma is a rare and aggressive malignancy with early local invasion and high metastatic potential, leading to poor outcomes. Limited to case reports, the literature offers little guidance on standardized treatment. We report a case of a 71-year-old male with a year-long history of perianal pain and painful defecation, following decades of mild anal discomfort. He underwent hemorrhoidectomy for presumed hemorrhoids, but histopathology revealed invasive malignant melanoma. On presentation, per rectal exam showed perianal satellite nodules and black pigmentation of the anal canal. Imaging confirmed anal canal thickening with hepatic and pulmonary metastases. Given the advanced stage and positive margins, the patient was managed palliatively with systemic chemotherapy.

摘要

肛管黑色素瘤是一种罕见且侵袭性强的恶性肿瘤,早期即可发生局部浸润,具有较高的转移潜能,导致预后较差。由于文献中仅限于病例报告,因此对于标准化治疗几乎没有指导意义。我们报告一例71岁男性患者,在经历数十年轻度肛管不适后,出现了长达一年的肛周疼痛和排便疼痛病史。他因疑似痔疮接受了痔切除术,但组织病理学检查显示为浸润性恶性黑色素瘤。就诊时,经直肠检查发现肛周有卫星结节以及肛管黑色素沉着。影像学检查证实肛管增厚并伴有肝肺转移。鉴于患者处于晚期且切缘阳性,遂对其进行了全身化疗的姑息治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/453f/12401871/46050e9c042d/rjaf700f1.jpg

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