Fatih Ozden M, Kahvecioglu Dilek, Tas Melda, Cetinkaya Aslihan Kose, Oktem Ahmet
Department of Pediatrics, University of Health Sciences Ankara Training and Research Hospital, Ankara 06230, Turkey.
Department of Neonatology, University of Health Sciences Ankara Training and Research Hospital, Ankara 06230, Turkey.
Asian Biomed (Res Rev News). 2025 Sep 2;19(4):183-189. doi: 10.2478/abm-2025-0025. eCollection 2025 Aug.
Transcutaneous bilirubinometers provide a non-invasive method to estimate total serum bilirubin (TSB) using multiwavelength reflectance. However, their accuracy during phototherapy (PT) remains controversial due to decreased dermal bilirubin.
To assess the correlation between TSB and transcutaneous bilirubin (TcB) measured from covered and exposed skin areas before, during, and after PT.
In this prospective study, 70 neonates undergoing PT were assessed. TcB measurements were obtained from the exposed sternum and the forehead, which were covered with an aluminum-coated radiopaque patch. TSB and TcB values were measured before PT, at 24 h during treatment, and 8 h post-treatment. The agreement between TSB and TcB values was evaluated using the intraclass correlation coefficient (ICC).
TcB values of covered skin showed significant correlation with TSB at all-time points (ICC = 0.665 for pre-PT, ICC = 0.520 at 24 h, and ICC = 0.537 for post-treatment). TcB values of exposed skin showed poor correlation during and after PT. Mean differences between covered TcB and TSB remained within acceptable limits (<1 mg/dL).
TcB measurements from covered skin offer a reliable, non-invasive alternative to serum bilirubin levels in neonates receiving PT, reducing the need for repeated blood draws.
经皮胆红素测定仪提供了一种使用多波长反射率来估算总血清胆红素（TSB）的非侵入性方法。然而，由于皮肤胆红素减少，其在光疗（PT）期间的准确性仍存在争议。
评估在光疗前、光疗期间和光疗后，从覆盖和暴露皮肤区域测量的TSB与经皮胆红素（TcB）之间的相关性。
在这项前瞻性研究中，对70名接受光疗的新生儿进行了评估。从暴露的胸骨和前额获取TcB测量值，前额用铝涂层不透射线贴片覆盖。在光疗前、治疗24小时时和治疗后8小时测量TSB和TcB值。使用组内相关系数（ICC）评估TSB和TcB值之间的一致性。
覆盖皮肤的TcB值在所有时间点均与TSB显示出显著相关性（光疗前ICC = 0.665，24小时时ICC = 0.520，治疗后ICC = 0.537）。暴露皮肤的TcB值在光疗期间和光疗后显示出较差的相关性。覆盖的TcB与TSB之间的平均差异保持在可接受范围内（<1mg/dL）。
对于接受光疗的新生儿，从覆盖皮肤测量的TcB提供了一种可靠的、非侵入性的替代血清胆红素水平的方法，减少了重复采血的需求。
