Khalil Atif Ali Khan, Bae Hanhong
Department of Biotechnology, Yeungnam University, Gyeongsan Gyeongbuk, 38541, Republic of Korea.
Institute of EcoBioMaterials, Gyeongsan Gyeongbuk, 38541, Republic of Korea.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Sep 4. doi: 10.1007/s00210-025-04531-y.
Alnus japonica, a deciduous tree native to East Asia, has garnered significant attention due to its ecological and pharmacological properties. As a member of the Betulaceae family, this species contributes to forest stability through nitrogen fixation and soil improvement. In addition to its environmental importance, Alnus japonica has been investigated for its potential therapeutic benefits, owing to its rich bioactive compounds, including diarylheptanoids, flavonoids, tannins, and phenolic acids. Recent studies report its anticancer, antioxidant, anti-inflammatory, hepatoprotective, lipid-regulating, and other activities, supporting its relevance in traditional and modern medicine. These bioactive constituents modulate key cellular pathways, particularly those involved in oxidative stress and immune response. This review aims to present the first comprehensive assessment of Alnus japonica, offering an in-depth analysis of its chemical composition, bioactivities, and potential mechanisms of action.
日本桤木是一种原产于东亚的落叶乔木，因其生态和药理特性而备受关注。作为桦木科的一员，该物种通过固氮和改良土壤来促进森林稳定。除了其环境重要性外，由于日本桤木富含生物活性化合物，包括二芳基庚烷类、黄酮类、单宁和酚酸，因此人们对其潜在的治疗益处进行了研究。最近的研究报告了它的抗癌、抗氧化、抗炎、保肝、调节脂质等活性，支持了它在传统医学和现代医学中的相关性。这些生物活性成分调节关键的细胞途径，特别是那些参与氧化应激和免疫反应的途径。本综述旨在首次对日本桤木进行全面评估，深入分析其化学成分、生物活性和潜在作用机制。
