Bendesky Andres
Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Ecology, Evolution and Environmental Biology, Columbia University, New York, NY 10027, USA; Kavli Institute for Brain Science, Columbia University, New York, NY 10027, USA.
Curr Opin Genet Dev. 2025 Sep 2;95:102397. doi: 10.1016/j.gde.2025.102397.
Recent advances in single-cell genomics are propelling a flurry of discoveries about the cellular composition of the brain and other organs across species. These discoveries, coupled with experimental manipulations, have begun to reveal how variation between species in the proportion of cell types, including the outright disappearance of some cell types and the emergence of new ones, contributes to the evolution of behavior. This review highlights these emerging findings in the context of more traditional approaches to study the evolution of behavior and discusses important outstanding questions in this field.
单细胞基因组学的最新进展推动了一系列关于跨物种大脑和其他器官细胞组成的发现。这些发现,再加上实验操作,已经开始揭示物种间细胞类型比例的差异,包括某些细胞类型的完全消失和新细胞类型的出现,是如何促成行为进化的。本综述在更传统的研究行为进化方法的背景下突出了这些新发现,并讨论了该领域重要的悬而未决的问题。