Krug H
Zentralbl Allg Pathol. 1985;130(4):333-40.
We summarize our own cytophotometric and flow cytometric measurements from malignant tumors and premalignant lesions. DNA, non-histoprotein and dry mass (by interference microscopy) have been assessed. Ploidy and the compartments of the cell cycle were evaluated. For most tumors (cervix, breast, ovary, melanoma, larynx, oro-facial, bladder) a bad prognosis was suggested by the following cytophotometric findings: aneuploidy, polyploidy, and/or a high proportion of S-G2/M nuclei. This has been statistically confirmed for breast cancer by case studies conducted over a period of five years. Among the changes associated with lung cancer were alterations in protein content. Cytophotometric findings can provide useful additional information concerning a patient's prognosis.
我们总结了自己对恶性肿瘤和癌前病变进行的细胞光度测定和流式细胞术测量结果。评估了DNA、非组蛋白和干质量（通过干涉显微镜）。评估了倍性和细胞周期各时相。对于大多数肿瘤（子宫颈、乳腺、卵巢、黑色素瘤、喉、口腔面部、膀胱），以下细胞光度测定结果提示预后不良：非整倍体、多倍体和/或S-G2/M期细胞核的高比例。通过为期五年的病例研究，这一点在乳腺癌中得到了统计学证实。与肺癌相关的变化包括蛋白质含量的改变。细胞光度测定结果可为患者的预后提供有用的额外信息。
