Talyshinskiĭ A M, Bogdanovich N K
Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(12):1802-6.
The morphological characteristics of the hypothalamo-pituitary neurosecretory system (HPNS) were studied in 123 rats with an experimental abscess in the temporal area of the brain. It was found that changes in the HPNS in this pathology ran 2 stages corresponding to the periods of the development of the pyoinflammatory process in the cerebral tissue. In the first period (at the 3rd-10th day of the development of a cerebral abscess) the functional activity of the HPNS was inhibited: a decrease in both synthesis and excretion of neurohormones was evident. The mortality rate at this period was the highest (21 of 23 rats). At the second period (the 15th-30th day of experiment) there was an increase in the activity of neurosecretory nuclei and a decrease in the mortality rate (2 rats). It is suggested that the absence of NPNS activation was one of the causes of the high mortality rate at the first period of the experiment which was related to the direct damaging action of the abscess localized in the cerebral portions having the direct impact on the neurosecretory system.
对123只在脑颞叶区域有实验性脓肿的大鼠的下丘脑 - 垂体神经分泌系统（HPNS）的形态学特征进行了研究。发现该病理状态下HPNS的变化分为两个阶段，与脑组织脓性炎症过程的发展时期相对应。在第一阶段（脑脓肿形成后的第3 - 10天），HPNS的功能活动受到抑制：神经激素的合成和分泌均明显减少。此阶段的死亡率最高（23只大鼠中有21只）。在第二阶段（实验的第15 - 30天），神经分泌核的活动增加，死亡率降低（2只大鼠）。研究表明，实验第一阶段高死亡率的原因之一是NPNS未被激活，这与位于对神经分泌系统有直接影响的脑区的脓肿的直接损害作用有关。
