Danger Richard, Feseha Yodit, Brouard Sophie
CHU Nantes, Nantes Université, INSERM, Center for Research in Transplantation and Translational Immunology (CR2TI), UMR 1064, F-44000 Nantes, France.
LabEx IGO "Immunotherapy, Graft, Oncology", F-44000 Nantes, France.
Cancers (Basel). 2022 Feb 17;14(4):1011. doi: 10.3390/cancers14041011.
Research advances in homolog (TRIB) genes have established the consensus that this protein family plays roles in diverse biological conditions and regulates intracellular signaling networks and several human diseases. In this review, we focus on one member of the family, TRIB1, and its role at the crossroads of immune signaling. TRIB1 directly interacts with transcription factors such as FOXP3 and C/EBPα, with several signaling molecules such as MEK1 and MALT1 and directly acts on key cell signaling pathways such as the MAPK and NF-κB pathways. Altogether, these interactions emphasize that TRIB1 is at the center of major cell signaling pathways while TRIB1 has cell-specific roles, potentially depending on the expressing cells and binding partners. In this review, we describe its roles in immune cells and highlight the interacting partners explaining these functions which suggests TRIB1 as a precise mediator of cellular homeostasis as well as in different cancers and immune-related disorders.
同源（TRIB）基因的研究进展已达成共识，即该蛋白家族在多种生物学条件下起作用，并调节细胞内信号网络以及多种人类疾病。在本综述中，我们聚焦于该家族的一个成员TRIB1及其在免疫信号交叉点的作用。TRIB1直接与转录因子如FOXP3和C/EBPα相互作用，与多种信号分子如MEK1和MALT1相互作用，并直接作用于关键细胞信号通路如MAPK和NF-κB通路。总之，这些相互作用强调TRIB1处于主要细胞信号通路的中心，而TRIB1具有细胞特异性作用，这可能取决于表达细胞和结合伙伴。在本综述中，我们描述了它在免疫细胞中的作用，并突出了解释这些功能的相互作用伙伴，这表明TRIB1是细胞稳态以及不同癌症和免疫相关疾病的精确调节因子。
