Feng Xiaoyang, Sun Xiaolin, Liu Jia, Li Yan, Yao Yunhai, Fu Jianming, Gu Xudong
Department of Neurology, Zhejiang Province People's Hospital Haining Hospital, Haining, China.
Department of Rehabilitation Medicine, The Second Affiliated Hospital of Jiaxing University, The Second Hospital of Jiaxing, Jiaxing, China.
Front Aging Neurosci. 2025 Aug 20;17:1590783. doi: 10.3389/fnagi.2025.1590783. eCollection 2025.
This study aimed to investigate the effects of computer-assisted cognitive training (CACT) on cognitive function and activities of daily living in patients with post-stroke cognitive impairment. Additionally, it aimed to explore the changes in specific cognitive domains before and after treatment.
The study was a double-blind, randomized, controlled trial.
It took place in rehabilitation wards or outpatient clinics.
Sixty patients with post-stroke cognitive impairment took part in the study.
Participants were randomly assigned to either the control ( = 30) or the intervention group ( = 30). Both groups received conventional rehabilitation and cognitive training, and the intervention group additionally received CACT.
The primary outcome measures included the Mini-Mental State Examination (MMSE) and event-related potential (ERP) P300 for cognitive function, as well as the modified Barthel Index (MBI) for activities of daily living. Secondary outcomes were the Trail Making Test (TMT), the Symbol-Digit Modalities Test (SDMT), the Auditory Verb Learning Test-Huashan version (AVLT-H), the Boston Naming Test (BNT), and the Clock Drawing Test (CDT), which assessed cognitive function across specific domains.
Both groups showed significant improvements in MMSE, MBI, amplitude of P300, and latency of P300, with the intervention group demonstrating more pronounced improvements compared to the control group. In terms of specific cognitive domains, the intervention group exhibited greater improvements than the control group in TMT-A, TMT-B, and AVLT-H. Both groups showed improvements in SDMT and BNT, but the differences between the groups were not statistically significant. Additionally, there was no significant improvement in the CDT for either group before and after treatment.
CACT was found to improve patients' cognitive function, especially in areas of attention, executive function, and memory. It also effectively improved activities of daily living.
本研究旨在探讨计算机辅助认知训练（CACT）对中风后认知障碍患者认知功能和日常生活活动能力的影响。此外，还旨在探究治疗前后特定认知领域的变化。
该研究为双盲、随机、对照试验。
在康复病房或门诊进行。
60例中风后认知障碍患者参与了本研究。
参与者被随机分为对照组（n = 30）或干预组（n = 30）。两组均接受常规康复和认知训练，干预组额外接受CACT。
主要结局指标包括用于评估认知功能的简易精神状态检查表（MMSE）和事件相关电位（ERP）P300，以及用于评估日常生活活动能力的改良巴氏指数（MBI）。次要结局指标为连线测验（TMT）、符号数字模式测验（SDMT）、听觉词语学习测验-华山版（AVLT-H）、波士顿命名测验（BNT）和画钟测验（CDT），这些指标用于评估特定领域的认知功能。
两组患者的MMSE、MBI、P300波幅和P300潜伏期均有显著改善，与对照组相比，干预组的改善更为明显。在特定认知领域方面，干预组在TMT-A、TMT-B和AVLT-H方面的改善优于对照组。两组患者的SDMT和BNT均有改善，但组间差异无统计学意义。此外,两组患者治疗前后的CDT均无显著改善。
研究发现CACT可改善患者的认知功能，尤其是在注意力、执行功能和记忆方面。它还能有效改善日常生活活动能力。
