Canela-Xandri Anna, Tomàs-Badell Oriol, Balcells Mercè
ETSEAFiV, UdL Av. de l'Alcalde Rovira Roure, 191 25198 Lleida Spain
RSC Adv. 2025 Sep 3;15(38):31706-31722. doi: 10.1039/d5ra02149a. eCollection 2025 Aug 29.
A key challenge in industrial processes is replacing fossil-based solvents with sustainable, renewable alternatives while minimizing industrial waste and enhancing sustainability. Deep eutectic solvents (DESs), with their exceptional properties, offer a promising solution. These solvents can be tailored from a wide variety of hydrogen bond donors (HBDs) and acceptors (HBAs), making them highly customizable, cost-effective, and versatile. Moreover, their excellent biocompatibility and biodegradability position them as ideal candidates for green chemistry applications. DESs are easy to prepare and offer numerous advantages, often serving a dual role as both solvents and active catalysts, depending on their composition and molar ratios. One particularly interesting HBD component for DESs is -toluenesulfonic acid (PTSA)-a solid, stable, and affordable strong organic acid. PTSA interacts effectively with various HBAs, making it highly valuable for applications requiring strong acidity and proton availability. This review explores PTSA's diverse applications and highlights its untapped potential in DES formulations. Additionally, it provides insights into HBA selection tendencies based on specific applications and starting materials. By showcasing PTSA's advantageous properties and versatility, this review underscores its role in advancing green chemistry and fostering innovation in sustainable solvent development.
工业过程中的一个关键挑战是用可持续的可再生替代品取代基于化石的溶剂，同时尽量减少工业废物并提高可持续性。深共晶溶剂（DESs）凭借其卓越的性能提供了一个有前景的解决方案。这些溶剂可以由各种各样的氢键供体（HBDs）和受体（HBAs）定制而成，使其具有高度的可定制性、成本效益和多功能性。此外，它们出色的生物相容性和生物降解性使其成为绿色化学应用的理想候选者。DESs易于制备且具有众多优点，根据其组成和摩尔比，它们通常兼具溶剂和活性催化剂的双重作用。对于DESs来说，一种特别有趣的HBD成分是对甲苯磺酸（PTSA）——一种固体、稳定且价格低廉的强有机酸。PTSA能与各种HBAs有效相互作用，这使其在需要强酸性和质子可用性的应用中具有很高的价值。本综述探讨了PTSA的各种应用，并突出了其在DES配方中尚未开发的潜力。此外，它还提供了基于特定应用和起始材料的HBA选择倾向的见解。通过展示PTSA的有利特性和多功能性，本综述强调了其在推进绿色化学和促进可持续溶剂开发创新方面的作用。
