Tawade Shubham, Mullerpatan Rajani, Agarwal Bela
Department of Musculoskeletal Physiotherapy, MGM School of Physiotherapy, MGM Institute of Health Sciences, Navi Mumbai, Maharashtra, India.
Int J Exerc Sci. 2025 Sep 1;18(5):910-921. doi: 10.70252/LESB9473. eCollection 2025.
Osteoarthritis (OA) is a highly prevalent musculoskeletal condition. It is reported that knee OA progressively affects lower-extremity functioning. Evidence is lacking on when there is a substantial decline in function and whether this trend differs between males and females and disease severity. This study aimed to examine influence of gender and increasing grade of knee OA on lower-extremity function. Following Institutional Ethical Committee approval and signed-informed consent, 115 participants (57-males, 58-females), aged 40-65 years, with diagnosed knee OA (grade 1-4) were recruited. Lower-extremity function was studied using reliable and valid outcome variables such as muscle strength-endurance, joint motion, ground-level activity exposure and physical activity. The medial knee joint space width (JSW) decreased by 56.7%(males) and 49.2%(females) from grades 1 to 2 and by 29.6%(males) and 47.8%(females) from grades 3 to 4. Lower-extremity muscle strength and mobility measured by 30-second-deep-squat test declined by 62%(males) and 40.4%(females) from grades 1 to 2 and by 94.4%(males) and 60.9%(females) from grades 3 to 4. Lower-extremity muscle endurance measured by 30-second-chair-sit-to-stand test declined by 8.3%(males) and 7.1%(females) from grades 1 to 2 and by 31.6%(males) and 85.7%(females) from grades 3 to 4. Physical function decreased by 0.3%(males) and 2.3%(females) from grades 1 to 2 and by 22.7%(males) and 32.0%(females) from grades 3 to 4. Physical activity decreased by 27.6%(males) and 28.6%(females) from grades 1 to 2 and by 53.1%(males) and 60.7%(females) from grades 3 to 4. A substantial decline was observed from grades 3 to 4, when both males and females presented considerable reductions in lower-extremity function.
骨关节炎（OA）是一种高度普遍的肌肉骨骼疾病。据报道，膝关节骨关节炎会逐渐影响下肢功能。目前缺乏关于功能何时会大幅下降以及这种趋势在男性和女性之间以及疾病严重程度方面是否存在差异的证据。本研究旨在探讨性别和膝关节骨关节炎等级增加对下肢功能的影响。在获得机构伦理委员会批准并签署知情同意书后，招募了115名年龄在40 - 65岁之间、被诊断为膝关节骨关节炎（1 - 4级）的参与者（57名男性，58名女性）。使用可靠且有效的结果变量，如肌肉力量耐力、关节活动度、地面活动暴露和身体活动来研究下肢功能。内侧膝关节间隙宽度（JSW）从1级到2级，男性下降了56.7%，女性下降了49.2%；从3级到4级，男性下降了29.6%，女性下降了47.8%。通过30秒深蹲测试测量的下肢肌肉力量和活动能力从1级到2级，男性下降了62%，女性下降了40.4%；从3级到4级，男性下降了94.4%，女性下降了60.9%。通过30秒椅上坐立测试测量的下肢肌肉耐力从1级到2级，男性下降了8.3%，女性下降了7.1%；从3级到4级，男性下降了31.6%，女性下降了85.7%。身体功能从1级到2级，男性下降了0.3%，女性下降了2.3%；从3级到4级，男性下降了22.7%，女性下降了32.0%。身体活动从1级到2级，男性下降了27.6%，女性下降了28.6%；从3级到4级，男性下降了53.1%，女性下降了60.7%。从3级到4级观察到功能大幅下降，此时男性和女性的下肢功能均出现了显著降低。
