Andren-Sandberg A, Dawiskiba S, Ihse I
Acta Pathol Microbiol Immunol Scand A. 1985 Nov;93(6):351-8. doi: 10.1111/j.1699-0463.1985.tb03962.x.
An attempt was made to define the importance of accumulated carcinogen dose and of induction-time on the development of pancreatic tumors after administration of N-nitrosobis(2-hydroxypropyl)amine (BHP) to Syrian golden hamsters. The development and progression of ductal hyperplasia, the number of tumor-bearing animals, the number of cancer-bearing animals, the number of tumors per tumor-bearing animal, and the grade of histological differentiation were found to be related to the accumulated dose of the carcinogen given, as was survival-time. The duration of the period between the carcinogen administration and examination was another factor of importance for the same changes except for the grade of histological differentiation of cancers and for survival-time. Once ductal hyperplasia and tumor development had started, there were no signs of regression - but rather progression - even after cessation of carcinogen administration. It is concluded that the development (progression) of induced pancreatic cancer in the Syrian golden hamster is influenced by the accumulated carcinogen (BHP) dose and the duration of the experiment. The results emphasize the need for a strict standardization of the experimental design as well as for the histological evaluation when animal models are used for studies of the effect of factors or procedures with a possible influence on the rate of tumor development.
在给叙利亚金仓鼠施用N-亚硝基双（2-羟丙基）胺（BHP）后，人们试图确定累积致癌物剂量和诱导时间对胰腺肿瘤发生的重要性。发现导管增生的发展和进展、荷瘤动物的数量、患癌动物的数量、每只荷瘤动物的肿瘤数量以及组织学分化程度均与所给予致癌物的累积剂量有关，生存时间也是如此。除了癌症的组织学分化程度和生存时间外，致癌物给药与检查之间的时间段长度是影响相同变化的另一个重要因素。一旦导管增生和肿瘤发展开始，即使在停止致癌物给药后，也没有消退的迹象，而是持续进展。得出的结论是，叙利亚金仓鼠诱发胰腺癌的发展（进展）受累积致癌物（BHP）剂量和实验持续时间的影响。结果强调，在使用动物模型研究可能影响肿瘤发展速度的因素或程序的效果时，需要对实验设计以及组织学评估进行严格标准化。
