亚硝基化合物单次剂量致癌反应的比较研究。N-亚硝基双（2-羟丙基）胺对叙利亚金黄地鼠的影响。
Comparative studies of neoplastic response to a single dose of nitroso compounds. The effect of N-nitrosobis (2-hydroxypropyl)amine in Syrian golden hamsters.
作者信息
Pour P M, Salmasi S Z
出版信息
J Cancer Res Clin Oncol. 1982;102(3):265-9. doi: 10.1007/BF00411346.
Abstract
Single s.c. applications of N-nitrosobis(2-hydroxypropyl)amine (BHP) caused carcinogenic effects in adult Syrian golden hamsters at doses as low as 1/40 of the LD50. The tumor spectrum decreased at lower doses, which affected the pancreas more strongly than the liver, whereas higher doses exhibited a more pronounced hepatocarcinogenicity and also induced tumors in the respiratory tract, gallbladder, kidney, and vagina. These results demonstrated a potent pancreatic carcinogenic effect of BHP at the lowest dose level. Hence, the presence of BHP in the environment, even in small quantities, should be regarded as a potential hazard to human health.
摘要
单次皮下注射N-亚硝基双（2-羟丙基）胺（BHP），在成年叙利亚金仓鼠身上，低至半数致死量（LD50）的1/40剂量时就会产生致癌作用。在较低剂量下，肿瘤谱变窄，对胰腺的影响比对肝脏更强，而较高剂量则表现出更明显的肝癌致癌性，还会诱发呼吸道、胆囊、肾脏和阴道的肿瘤。这些结果表明，在最低剂量水平时，BHP就具有强大的胰腺致癌作用。因此，环境中即使存在少量的BHP，也应被视为对人类健康的潜在危害。
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本文引用的文献
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Synergistic effects of N-nitroso compounds in experimental long-term carcinogenesis studies.N-亚硝基化合物在实验性长期致癌研究中的协同作用。
Oncology. 1980;37(4):259-65. doi: 10.1159/000225448.
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The carcinogenicity of N-nitrosodiethanolamine, an environmental pollutant, in Syrian hamsters.环境污染物N-亚硝基二乙醇胺对叙利亚仓鼠的致癌性。
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A potent pancreatic carcinogen in Syrian hamsters: N-nitrosobis(2-oxopropyl)amine.叙利亚仓鼠体内一种强效的胰腺癌致癌物：N-亚硝基双（2-氧代丙基）胺。
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Selective induction of pancreatic ductular tumors by single doses of N-nitrosobis(2-oxopropyl)amine in Syrian golden hamsters.在叙利亚金黄地鼠中通过单剂量N-亚硝基双（2-氧代丙基）胺选择性诱导胰腺导管肿瘤
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J Natl Cancer Inst. 1975 Jan;54(1):141-6. doi: 10.1093/jnci/54.1.141.
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