Sagulin G B, Wroblewski J, Arver S, Roomans G M
Acta Physiol Scand. 1985 Dec;125(4):649-54. doi: 10.1111/j.1748-1716.1985.tb07767.x.
The effect of calcitonin on rat submandibular gland acinar cells was investigated by X-ray microanalysis and electron microscopy. Calcitonin caused a transient increase of the cellular calcium and magnesium concentration, but did not affect the intracellular concentration of other electrolytes. The relative volume of intracellular mucus increased from 45% in control glands to 72% at 6 h after administration of calcitonin. Calcitonin caused an inhibition of the cellular response of the acinar cells to beta-adrenergic and cholinergic agonists. The changes in elemental composition and ultrastructure of the gland cells are probably due to inhibition of mucus release from the cells.
通过X射线微量分析和电子显微镜研究了降钙素对大鼠下颌下腺腺泡细胞的作用。降钙素引起细胞钙和镁浓度短暂升高，但不影响其他电解质的细胞内浓度。细胞内黏液的相对体积从对照腺体的45%增加到降钙素给药后6小时的72%。降钙素抑制腺泡细胞对β-肾上腺素能和胆碱能激动剂的细胞反应。腺细胞元素组成和超微结构的变化可能是由于细胞黏液释放受到抑制所致。
