Bülow J, Madsen J, Astrup A, Christensen N J
Acta Physiol Scand. 1985 Dec;125(4):661-7. doi: 10.1111/j.1748-1716.1985.tb07769.x.
Subcutaneous or perirenal adipose tissue blood flow was measured with the 133Xe-washout technique before and after intravenous injection or infusion of Intralipid in six anesthetized, otherwise intact mongrel dogs. In four anesthetized mongrel puppies adipose tissue blood flow was measured with the radioactive microsphere method in seven different adipose tissue depots before a bolus injection of Intralipid and at the time after the injection when the thermogenic effect of the Intralipid was maximal. The results showed that the vascular resistance increased in all the examined adipose depots in adult as well as in young dogs after this treatment. The administration of Intralipid did not per se induce the vasoconstriction. The vasoconstriction took place simultaneously with increasing FFA/albumin molar ratios. The results support our previous findings in perfused fat pads that high molar FFA/albumin ratios increase vascular resistance in adipose tissue and they give further support to our suggestion that this vasoconstriction may be a link in a negative-feedback mechanism regulating FFA-mobilization in relation to FFA utilization.
在6只麻醉状态下、其他方面均健康的杂种犬中，于静脉注射或输注脂肪乳剂前后，采用¹³³Xe洗脱技术测量皮下或肾周脂肪组织血流量。在4只麻醉状态下的杂种幼犬中，于静脉推注脂肪乳剂前以及注射后脂肪乳剂产热效应最大时，采用放射性微球法测量7个不同脂肪组织部位的脂肪组织血流量。结果显示，经此处理后，成年犬和幼犬所有被检查的脂肪组织部位的血管阻力均增加。脂肪乳剂的给药本身并未引起血管收缩。血管收缩与游离脂肪酸/白蛋白摩尔比升高同时发生。这些结果支持了我们之前在灌注脂肪垫中的发现，即高摩尔比的游离脂肪酸/白蛋白会增加脂肪组织的血管阻力，并且进一步支持了我们的观点，即这种血管收缩可能是调节游离脂肪酸动员与游离脂肪酸利用相关的负反馈机制中的一个环节。
