You Xuedan, Reuschenbach Miriam, Jain Astha, Hall Adam, Jain Aastha, Villarejo Maria, Chen Ya-Ting, Durand Nancy
Department of Outcomes Research, Value and Implementation, Merck & Co., Inc., Rahway, NJ, USA.
Department of Global Medical & Scientific Affairs, MSD Sharp & Dohme GmbH, Munich, Germany.
Hum Vaccin Immunother. 2025 Dec;21(1):2550095. doi: 10.1080/21645515.2025.2550095. Epub 2025 Sep 5.
HPV vaccination in adults provides opportunities for individuals who were previously ineligible, or who missed vaccination as adolescents, thereby reducing HPV-related disease burden. This targeted literature review summarizes the HPV vaccination recommendations and guidelines by National Immunization Technical Advisory Groups and professional societies, and public funded programs for adults. Of the 152 jurisdictions examined, 62 offered HPV vaccination recommendations for general adults. Of these, 84% included both genders and 68% included sub-populations. Four jurisdictions had recommendations for adult sub-populations only. Overall, 38 jurisdictions had funded programs for general adults and 17 targeted specific sub-populations. The most reported upper eligible age for recommendations or guidelineswas 26 y and 45 y, and 26 y for funded programs. People with HIV and immunosuppressed individuals were the most common sub-populations included. While economic reasons may influence funding for HPV vaccination among adults, clinical guidelines are more likely to advise vaccination on an individual basis, regardless of age.
成人接种人乳头瘤病毒(HPV)疫苗为以前不符合条件或青少年时期错过接种的个体提供了机会,从而减轻了与HPV相关的疾病负担。这项有针对性的文献综述总结了国家免疫技术咨询小组和专业协会针对成人的HPV疫苗接种建议和指南,以及公共资助项目。在审查的152个司法管辖区中,62个为普通成年人提供了HPV疫苗接种建议。其中,84%的建议涵盖了男女两性,68%的建议涵盖了亚人群。四个司法管辖区仅针对成人亚人群提出了建议。总体而言,38个司法管辖区为普通成年人提供了资助项目,17个针对特定亚人群。建议或指南中报告最多的年龄上限为26岁和45岁,资助项目的年龄上限为26岁。艾滋病毒感染者和免疫功能低下者是最常见的纳入亚人群。虽然经济因素可能会影响成人HPV疫苗接种的资金投入,但临床指南更可能建议根据个体情况进行接种,而不考虑年龄。