Huang Lili, Liu Zhenhua, Bai Zhenjiang, Zhou Mi, Lv Panpan, Jiang Yue, Chen Mingliang
Laboratory Department, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China.
Infection. 2025 Sep 5. doi: 10.1007/s15010-025-02638-1.
A 23-month-old boy was admitted to our hospital with onset of fever and paroxysmal cough but progressed to death on Day 9. Streptococcus pyogenes was positive in cerebrospinal fluid and blood by next-generation sequencing, and was cultured from sputum. The isolate was resistant to erythromycin, clindamycin, and tetracycline. By genomic analysis, the isolate was identified to be emm12 of global Clade II and harbor mobile genetic elements of ICE-emm12 and ΦHKU.vir, carrying resistance genes ermB and tetM. We report a fatal case of meningitis case complicated with streptococcal toxic shock syndrome caused by emm12 S. pyogenes in China, which is rare in this country.
一名23个月大的男孩因发热和阵发性咳嗽入院，于第9天死亡。通过下一代测序，脑脊液和血液中的化脓性链球菌呈阳性，痰液培养出该菌。分离株对红霉素、克林霉素和四环素耐药。通过基因组分析，该分离株被鉴定为全球进化枝II的emm12，含有ICE-emm12和ΦHKU.vir的移动遗传元件，携带耐药基因ermB和tetM。我们报告了中国一例由emm12化脓性链球菌引起的致命性脑膜炎合并链球菌中毒性休克综合征病例，此病例在该国较为罕见。
