Petrelli F, Moretti P, Sciarresi P, Dahir A M
Acta Vitaminol Enzymol. 1985;7(3-4):199-206.
Biotin-deficient rats show a slower growth rate and a reduction in thymus, intestinal lymph nodes and spleen weight. The effect is reversible. Biotin administration to normal rats (1 mg/rat/day) causes an increase in intestinal lymph nodes and spleen, while there is no effect on body and thymus weight. The amount of thymus and spleen DNA is lower for deficient than control rats. No difference was noticed between the levels of DNA from normal control and biotin-deficient rat lymph nodes, and between the levels of DNA from normal rats treated and untreated with biotin. The time-course of the specific radioactivity of DNA and the DNA turnover shows that biotin increases both the incorporation of labelling in DNA and DNA turnover rate.
生物素缺乏的大鼠生长速率较慢，胸腺、肠淋巴结和脾脏重量减轻。这种影响是可逆的。给正常大鼠注射生物素（1毫克/大鼠/天）会导致肠淋巴结和脾脏增大，而对体重和胸腺重量没有影响。缺乏生物素的大鼠胸腺和脾脏的DNA含量低于对照大鼠。正常对照大鼠和生物素缺乏大鼠淋巴结的DNA水平之间，以及用生物素处理和未处理的正常大鼠的DNA水平之间均未发现差异。DNA的比放射性和DNA周转率的时间进程表明，生物素可增加DNA中标记物的掺入量和DNA周转率。
