Petrelli F, Moretti P, Paparelli M, Guglielmi L, Barra D
Arch Int Physiol Biochim. 1980 May;88(2):163-8. doi: 10.3109/13813458009075681.
Biotin-deficient rats show a slowing down of the growth and an involution of the thymus. The amount of the thymic peptides controlling DNA template, if referred to the thymus weight is higher in deficient than in control rats; no significant difference is noticed among the contents of the active peptides when evaluated per rat. The inhibiting activity on RNA synthesis is the same for the peptides extracted from normal and from biotin-deficient rat thymus.
生物素缺乏的大鼠生长减缓，胸腺萎缩。若以胸腺重量为参照，控制DNA模板的胸腺肽量在缺乏生物素的大鼠中高于对照大鼠；但按每只大鼠计算，活性肽含量未观察到显著差异。从正常大鼠和生物素缺乏大鼠胸腺中提取的肽对RNA合成的抑制活性相同。
