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认知缺陷与长期酗酒的关系。

Cognitive deficits as a function of years of alcohol abuse.

作者信息

DeFranco C, Tarbox A R, McLaughlin E J

出版信息

Am J Drug Alcohol Abuse. 1985;11(3-4):279-93. doi: 10.3109/00952998509016866.

Abstract

The present study relates duration of alcohol abuse and degree of cognitive impairment among a population of alcohol dependent subjects (DSM-III). Data on 175 consecutively admitted patients were first examined to empirically establish operational definitions of short-term and long-term alcohol abuse for this population. Five or more consecutive years of alcohol abuse was thus defined by a median split as long-term alcoholism. The next 125 consecutive admissions were subsequently identified as either Short-Term or Long-Term alcoholics according to this criterion. Data gathered from these 125 subjects represented a wide range of neuropsychological measures. Analyses showed that Long-Term alcoholics demonstrated significantly greater cognitive deficits on tasks of psychomotor speed, recent memory, and overall alertness relative to less chronic alcoholics. This pattern occurred independent of age and education. These findings are interpreted in terms of a cognitive typology of alcoholism, and implications for treatment, including aftercare and cognitive remediation techniques, are discussed.

摘要

本研究探讨了酒精依赖患者群体(DSM-III)中酒精滥用的持续时间与认知障碍程度之间的关系。首先对175例连续入院患者的数据进行了检查,以便从经验上为本群体确定短期和长期酒精滥用的操作性定义。因此,通过中位数分割将连续五年或更长时间的酒精滥用定义为长期酗酒。随后,根据这一标准,将接下来连续入院的125例患者确定为短期或长期酗酒者。从这125名受试者收集的数据代表了广泛的神经心理学测量指标。分析表明,与酗酒时间较短的患者相比,长期酗酒者在心理运动速度、近期记忆和整体警觉性任务上表现出明显更大的认知缺陷。这种模式不受年龄和教育程度的影响。这些发现依据酒精中毒的认知类型学进行了解释,并讨论了其对治疗的影响,包括后期护理和认知矫正技术。

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