Zadrobilek E, Schindler I, Jantsch H, Gilly H, Mauritz W, Draxler V, Sporn P, Steinbereithner K
Anaesthesist. 1985 Nov;34(11):582-7.
To evaluate the accuracy of the method, sequential measurements (n = 159) of extravascular lung water (EVLW) using the thermo-dye double-indicator dilution technique were performed in 22 critically surgical ill patients. Radiographic grading of lung water content served as clinical standard. Normal mean EVLW defined radiographically without evidence of pulmonary edema was 4.8 +/- 1.1 ml/kg. Early interstitial fluid accumulation was quite accurately detected with 6.9 +/- 2.1 ml/kg EVLW (p less than 0.001 vs normal lung water content). The mean EVLW present with definitive interstitial and alveolar edema was 11.5 +/- 3.8 ml/kg and 19.1 +/- 4.5 ml/kg, respectively. Despite some objections to the method (diffusion limitation of the thermal indicator, uneven regional lung perfusion), this technique for measuring EVLW reliably assesses the degree of pulmonary edema. Even when properly performed, chest roentgenograms only confirm gross changes in the lung water content.
为评估该方法的准确性,采用热染料双指示剂稀释技术对22例外科重症患者进行了血管外肺水(EVLW)的连续测量(n = 159)。肺水含量的影像学分级作为临床标准。影像学上定义的无肺水肿证据的正常平均EVLW为4.8±1.1 ml/kg。当EVLW为6.9±2.1 ml/kg时可相当准确地检测到早期间质液积聚(与正常肺水含量相比,p<0.001)。明确的间质和肺泡水肿时的平均EVLW分别为11.5±3.8 ml/kg和19.1±4.5 ml/kg。尽管对该方法存在一些异议(热指示剂的扩散限制、肺区域灌注不均),但这种测量EVLW的技术能可靠地评估肺水肿程度。即使操作得当,胸部X线片也只能证实肺水含量的大体变化。