基因阳性（MYBPC3）非梗阻性肥厚型心肌病患者室间隔广泛钙化
Extensive Calcification of the Ventricular Septum in Gene-Positive (MYBPC3) Nonobstructive Hypertrophic Cardiomyopathy.
作者信息
Hundal Prabhjot, Nahhas Omar, Jan M Fuad, Tajik A Jamil, Galazka Patrycja
机构信息
Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St Luke's Medical Centers, Milwaukee, Wisconsin, USA.
Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St Luke's Medical Centers, Milwaukee, Wisconsin, USA; Division of Cardiovascular Medicine, University of Wisconsin School of Medicine and Public Health, Milwaukee Clinical Campus, Milwaukee, Wisconsin, USA.
出版信息
JACC Case Rep. 2025 Sep 3;30(26):104887. doi: 10.1016/j.jaccas.2025.104887.
IMAGES
We present multimodality imaging of ventricular septal calcification.
CASE SUMMARY
A 38-year-old man with asymptomatic gene-positive hypertrophic cardiomyopathy was found to have extensive dystrophic calcification of the ventricular septum. We hypothesized that the extensive ventricular septal calcification would represent an area of severe myocardial fibrosis, resulting in calcification secondary to postsurgical (septal myectomy) changes.
TAKE-HOME MESSAGE: Calcification of the ventricular septum is a rare finding, not previously described following septal myectomy, that should prompt a comprehensive evaluation and follow-up with multimodality imaging and testing.
影像
我们展示了室间隔钙化的多模态成像。
病例总结
一名38岁基因阳性无症状肥厚型心肌病男性被发现存在广泛的室间隔营养不良性钙化。我们推测广泛的室间隔钙化代表严重心肌纤维化区域，继发于手术（室间隔心肌切除术）改变后出现钙化。
要点
室间隔钙化是一种罕见发现，此前未在室间隔心肌切除术后被描述过，这应促使进行多模态成像和检测的全面评估及随访。
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