Liu Chunyun, Liu Xiaohua, Zhou Min, Yao Jinhui, Zhang Shizhou, Zhao Ting
Department of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250014, China.
Department of Oral Outpatient Service, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250014, China.
Support Care Cancer. 2025 Sep 6;33(10):836. doi: 10.1007/s00520-025-09886-9.
This study examines the effects of preoperative oral carbohydrates on the perioperative period of Fibula Free Flap surgery in oral cancer patients, aiming to enhance postoperative recovery.
The study involved 89 patients who underwent fibula flap reconstruction surgery from January to December 2023. Patients were divided into control and experimental groups based on admission time. The control group followed standard fasting guidelines, while the experimental group received 800 mL and 200 mL of carbohydrates solution orally at 10 and 2 h pre-surgery, respectively. Data collected for both groups included comfort levels, blood glucose, surgical duration, intraoperative blood loss, fluid replacement, albumin, prealbumin, hemoglobin, PCT, IL-6, flap crisis, wound infection, bleeding, thrombosis, gastrointestinal reactions, extubation time, hospital stay, and total cost. All data were statistically analyzed.
The experimental group reported significantly lower thirst and hunger one hour pre-surgery (p < 0.0001) and had lower blood glucose levels one day post-surgery (p = 0.0003) compared to the control group. No significant differences were observed in other preoperative or postoperative measures.
Preoperative oral carbohydrates improve comfort and stabilize blood glucose levels in patients undergoing oral cancer fibula flap surgery, positively influencing perioperative management. This approach is beneficial for patients receiving this type of surgery.
本研究探讨术前口服碳水化合物对口腔癌患者游离腓骨瓣手术围手术期的影响，旨在促进术后恢复。
本研究纳入了2023年1月至12月期间接受腓骨瓣重建手术的89例患者。根据入院时间将患者分为对照组和实验组。对照组遵循标准禁食指南，而实验组分别在术前10小时和2小时口服800mL和200mL碳水化合物溶液。收集两组患者的舒适度、血糖、手术时间、术中出血量、液体补充量、白蛋白、前白蛋白、血红蛋白、降钙素原（PCT）、白细胞介素-6（IL-6）、皮瓣危象、伤口感染、出血、血栓形成、胃肠道反应、拔管时间、住院时间和总费用等数据。所有数据均进行统计学分析。
与对照组相比，实验组在术前1小时的口渴和饥饿感明显较低（p<0.0001），术后1天的血糖水平也较低（p = 0.0003）。在其他术前或术后指标方面未观察到显著差异。
术前口服碳水化合物可改善口腔癌腓骨瓣手术患者的舒适度并稳定血糖水平，对围手术期管理产生积极影响。这种方法对接受此类手术的患者有益。
