红霉素A、B、C和D及其某些衍生物的抗菌活性。
Antibacterial activities of erythromycins A, B, C, and D and some of their derivatives.
作者信息
Kibwage I O, Hoogmartens J, Roets E, Vanderhaeghe H, Verbist L, Dubost M, Pascal C, Petitjean P, Levol G
出版信息
Antimicrob Agents Chemother. 1985 Nov;28(5):630-3. doi: 10.1128/AAC.28.5.630.
Abstract
The MICs of erythromycins A, B, C, and D and some of their derivatives were determined against 21 gram-positive and 15 gram-negative microorganisms. Antibacterial activity was confined to gram-positive and very few gram-negative bacteria. Erythromycin B was somewhat less active than erythromycin A, and erythromycin C and D showed about half that activity or even less. Most other derivatives had negligible activity. Determination of potency by diffusion and turbidimetric assays were in line with MICs. The examination of the results of these assays, however, revealed that there are differences between the data of different laboratories, depending on the microorganisms and conditions used.
摘要
测定了红霉素A、B、C和D及其一些衍生物对21种革兰氏阳性菌和15种革兰氏阴性菌的最低抑菌浓度（MIC）。抗菌活性仅限于革兰氏阳性菌和极少数革兰氏阴性菌。红霉素B的活性略低于红霉素A，而红霉素C和D的活性约为红霉素A的一半或更低。大多数其他衍生物的活性可忽略不计。通过扩散法和比浊法测定的效价与最低抑菌浓度结果一致。然而，对这些测定结果的检查表明，不同实验室的数据存在差异，这取决于所使用的微生物和条件。
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