铜二肽复合物对悉生小鼠肠道中永存梭菌菌株定植的抑制作用。
Inhibitory effect of a copper-dipeptide complex on the establishment of a Clostridium perenne strain in the intestinal tract of gnotobiotic mice.
作者信息
Dubos F, Pelissier J P, Andrieux C, Ducluzeau R, Raibaud P
出版信息
Appl Environ Microbiol. 1985 Nov;50(5):1258-61. doi: 10.1128/aem.50.5.1258-1261.1985.
Abstract
A semisynthetic diet fed to axenic mice was found to prevent the establishment of a Clostridium perenne strain in their intestinal tract. This inhibitory effect did not occur when axenic mice were preinoculated with a strain of Clostridium difficile. The inhibitory effect was related to the presence in the intestinal contents of axenic mice of both dietary copper and a dipeptide, aspartic-epsilon-lysine. When C. difficile was inoculated into axenic mice, the dipeptide disappeared from the digesta, and C. perenne became established even in the presence of high concentrations of copper.
摘要
给无菌小鼠喂食半合成饮食可防止肠道内梭状芽孢杆菌菌株的定植。当无菌小鼠预先接种艰难梭菌菌株时，这种抑制作用不会发生。抑制作用与无菌小鼠肠道内容物中膳食铜和二肽天冬氨酸-ε-赖氨酸的存在有关。当将艰难梭菌接种到无菌小鼠体内时，二肽会从消化物中消失，即使存在高浓度的铜，梭状芽孢杆菌也会定植。
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本文引用的文献
1
Remanent effect of some dietary regimens on the establishment of two Clostridium strains in the digestive tract of gnotobiotic mice.某些饮食方案对悉生小鼠消化道中两种梭菌菌株定植的残留影响。
Am J Clin Nutr. 1981 Apr;34(4):520-6. doi: 10.1093/ajcn/34.4.520.
2
Inhibitory effect of dietary soybean meal on the establishment of a Clostridium strain in the gastrointestinal tract of mice.日粮豆粕对小鼠胃肠道中一株梭菌定植的抑制作用。
Infect Immun. 1982 May;36(2):621-7. doi: 10.1128/iai.36.2.621-627.1982.
3
beta-Aspartyl-epsilon-lysine, a peptide of the fecal contents of axenic mice.β-天冬氨酰-ε-赖氨酸，一种无菌小鼠粪便内容物中的肽。
Reprod Nutr Dev (1980). 1983;23(3):509-15.
4
A radiometric assay of copper binding in biological fluids and its application to alimentary secretions in normal subjects and Wilson's disease.生物体液中铜结合的放射性测定及其在正常受试者和威尔逊病患者消化液中的应用。
Clin Chim Acta. 1971 Jan;31(1):197-204. doi: 10.1016/0009-8981(71)90378-0.
5
[Microflora of the digestive system of the rat. I. Technics of study and proposed culture media].[大鼠消化系统的微生物区系。I. 研究技术及推荐的培养基]
Ann Inst Pasteur (Paris). 1966 Apr;110(4):568-90.
6
[The colonisation of the gut "gnotoxenic" rats and mice with 10 strains of stricty anaerobic bacteria. The influence of the host and of its diet].[用10株严格厌氧菌对“无毒菌”大鼠和小鼠的肠道进行定殖。宿主及其饮食的影响]
Ann Microbiol (Paris). 1973 Dec;124(4):517-32.
7
Diet and the equilibrium between bacteria and yeast implanted in gnotobiotic rats.饮食与悉生大鼠体内植入的细菌和酵母之间的平衡
Am J Clin Nutr. 1972 Dec;25(12):1467-74. doi: 10.1093/ajcn/25.12.1467.
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Am J Clin Nutr. 1972 Dec;25(12):1329-34. doi: 10.1093/ajcn/25.12.1329.
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10
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