Ducluzeau R, Dubos F, Raibaud P, Abrams G D
Antimicrob Agents Chemother. 1976 Jan;9(1):20-5. doi: 10.1128/AAC.9.1.20.
A strain of Bacillus licheniformis, established in the digestive tract of gnotobiotic mice, inhibited the subsequent establishment of a Clostridium perfringens strain ingested by the animals. This inhibitory effect depended on the in vivo production by B. licheniformis of an antibiotic substance having a number of the characteristics of bacitracin. If C. perfringens was the first to become established in the digestive tract of the gnotobiotic mice, B. licheniformis also became established but did not produce any antibiotic. Mutants of C. perfringens resistant to the antibiotic substance were not observed when the antibiotic was produced in situ by B. licheniformis, but were rapidly selected when the Bacillus culture filtrate or bacitracin was administered per os. B. licheniformis was also capable of eliminating from the digestive tract 5 of the 13 additional bacterial strains tested.
在无菌小鼠消化道中定植的一株地衣芽孢杆菌，可抑制动物随后摄入的产气荚膜梭菌菌株的定植。这种抑制作用取决于地衣芽孢杆菌在体内产生的一种具有杆菌肽多种特性的抗生素物质。如果产气荚膜梭菌最先在无菌小鼠的消化道中定植，地衣芽孢杆菌也会定植，但不会产生任何抗生素。当地衣芽孢杆菌在原位产生抗生素时，未观察到对该抗生素物质具有抗性的产气荚膜梭菌突变体，但当经口给予芽孢杆菌培养滤液或杆菌肽时，会迅速筛选出突变体。地衣芽孢杆菌还能够从消化道中清除所测试的另外13种细菌菌株中的5种。
