Dikshteĭn E A, Vasilenko I V, Rovenskaia N M, Orlova N L, Kurennaia S S
Arkh Patol. 1985;47(11):51-7.
Histochemical, morphological and ultrastructural studies of 208 cases of carcinoma of various organs (stomach, colon, lung, mammary gland, bladder, thyroid) and 159 cases of precancerous or risk disease of these organs are given. The degree and properties of local immune reactions in precancer, incipient and advanced carcinoma are compared. The degree of the epithelium and stroma infiltration with the immunocompetent cells as well as the cell composition of the infiltrate vary at different stages of tumour development and depending on its histological structure. Cytotoxic effect of the immunocompetent cells on the tumour cells is revealed, this effect decreasing in advanced carcinoma.
对208例不同器官（胃、结肠、肺、乳腺、膀胱、甲状腺）的癌以及159例这些器官的癌前或风险疾病进行了组织化学、形态学和超微结构研究。比较了癌前、早期和晚期癌中局部免疫反应的程度和特性。在肿瘤发展的不同阶段以及根据其组织结构，免疫活性细胞对上皮和间质的浸润程度以及浸润细胞的组成各不相同。揭示了免疫活性细胞对肿瘤细胞的细胞毒性作用，这种作用在晚期癌中减弱。
