Liang Shifu, Zhu Xiurong, Zheng Yanxue, Zhao Hong, Zhou Li, Wu Youlin
Department of Neurology, Chongzhou People's Hospital, Sichuan, People's Republic of China.
Department of Neurology, Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Int Med Case Rep J. 2025 Aug 30;18:1117-1125. doi: 10.2147/IMCRJ.S535706. eCollection 2025.
Fluoroacetamide, a commonly used convulsant rodenticide, can rapidly damage the nervous, digestive, and cardiovascular systems, potentially leading to fatal outcomes if ingested. This study reports the case of a 62-year-old Chinese woman who presented with symptoms of intoxication, including slurred speech, agitation, and seizure-like episodes, accompanied by gastrointestinal symptoms such as vomiting, skin bruising, and mild liver dysfunction. Toxin analysis revealed the presence of fluoroacetate in her blood and urine, and diffusion weighted imaging (DWI) imaging indicated white matter lesions, leading to the diagnosis of rare fluoroacetamide poisoning. This diagnosis facilitated the administration of treatments including vitamin K, hemodialysis, acetamide, and calcium gluconate. The patient subsequently regained consciousness, with improvements in laboratory results and gradual resolution of toxic-metabolic encephalopathy. This case highlights the importance of considering drug poisoning in patients with challenging neurological symptoms, particularly when there is a potential history of drug ingestion. Accurate diagnosis of such conditions is crucial, as timely and appropriate treatment can significantly improve clinical outcomes.
氟乙酰胺是一种常用的惊厥性灭鼠剂，若被摄入，可迅速损害神经、消化和心血管系统，有可能导致致命后果。本研究报告了一名62岁中国女性的病例，她出现中毒症状，包括言语不清、烦躁不安和癫痫样发作，伴有呕吐、皮肤瘀伤和轻度肝功能不全等胃肠道症状。毒素分析显示其血液和尿液中存在氟乙酸盐，弥散加权成像（DWI）显示白质病变，从而诊断为罕见的氟乙酰胺中毒。这一诊断促使采取了包括维生素K、血液透析、乙酰胺和葡萄糖酸钙在内的治疗措施。患者随后恢复意识，实验室检查结果有所改善，中毒性代谢性脑病逐渐得到缓解。该病例强调了在有挑战性神经症状的患者中考虑药物中毒的重要性，特别是当存在潜在药物摄入史时。准确诊断此类疾病至关重要，因为及时、恰当的治疗可显著改善临床结局。
