Liang Huan, Deng Pin, Yang Lili, Yuan Yusong, Ding Xiaofang
Beijing Longfu Hospital, Beijing, China.
Institute of Basic Theory of Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Front Endocrinol (Lausanne). 2025 Aug 21;16:1635004. doi: 10.3389/fendo.2025.1635004. eCollection 2025.
Diabetic foot ulcers (DFUs) represent a prevalent complication of diabetes, with a lifetime risk ranging from 15% to 25% among diabetic patients. Research indicates that anticoagulation plays a crucial role in the management of newly diagnosed cases of diabetic lower extremity atherosclerotic obliterative disease. However, in the present case, the patient developed dry gangrene in both toes after receiving vasodilator drugs during an emergency intervention for sudden aortic dissection. Given that traditional treatments, such as anticoagulation and transfemoral amputation, may not be appropriate for every case, it is imperative to explore alternative therapeutic options. This case report presents pioneering clinical evidence of a tri-therapeutic strategy integrating biomechanical conditioning transverse tibial bone transport (TTBT), Traditional Chinese Medicine Compress Therapy (TCM-CT), and antibiotic-loaded bone cement (ALBC) for diabetic foot ulcer regeneration. This innovative paradigm demonstrates concurrent activation of mechanobiological signaling pathways, phytochemical bioactivity, and sustained antimicrobial protection, achieving complete epithelialization in refractory neuropathic wounds.
糖尿病足溃疡（DFUs）是糖尿病常见的并发症，糖尿病患者一生中发生DFUs的风险为15%至25%。研究表明，抗凝在糖尿病下肢动脉粥样硬化闭塞症新诊断病例的治疗中起着关键作用。然而，在本病例中，患者在因突发主动脉夹层进行紧急干预期间接受血管扩张剂治疗后，双足趾出现干性坏疽。鉴于传统治疗方法，如抗凝和经股截肢，可能并不适用于所有病例，探索替代治疗方案势在必行。本病例报告展示了一种三联治疗策略的开创性临床证据，该策略整合了生物力学调节横向胫骨骨搬运（TTBT）、中药敷贴疗法（TCM-CT）和载抗生素骨水泥（ALBC），用于糖尿病足溃疡再生。这种创新模式显示出机械生物学信号通路、植物化学生物活性的同时激活以及持续的抗菌保护，在难治性神经性伤口中实现了完全上皮化。
