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金纳米粒子作为治疗剂载体的兴起。

Rise of gold nanoparticles as carriers of therapeutic agents.

机构信息

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出版信息

Acta Chim Slov. 2023 Nov 2;70(4):467-478. doi: 10.17344/acsi.2023.8216.

Abstract

A nanoparticle is the simplest structural component due to its nanometer-sized diameter. Nanoparticles are typically atoms or molecules that generate a radius (or diameter) of less than 100 nm when bonded collectively. The latest developments in nanotechnology provide a wide range of methods for studying and monitoring various medical and biological processes at the nanoscale. Nanoparticles can help diagnose and treat diseases, such as cancer, by carrying drugs directly to cancer cells. They can also be used to detect disease biomarkers in the body, helping to provide early diagnosis. It is likely that the data will have a positive effect on biology and medicine. It is plausible that nanoparticles could be used in theranostic applications and targeted drug delivery. This could significantly improve patient outcomes and reduce the amount of time, effort, and money needed to diagnose and treat diseases. It could also reduce the side effects of treatments, providing more precise and effective treatments. Nanoparticles for biomedical applications include polymeric and metal nanoparticles; liposomes and micelles; dendrimers and quantum dots; etc. Among the nanoparticles, gold nanoparticles have emerged as a promising platform for drug delivery applications. Gold nanoparticles are highly advantageous for drug delivery applications due to their excellent biocompatibility, stability, and tunable physical and chemical properties. The present review provides an in-depth discussion of the various approaches to gold nanoparticle synthesis and drug delivery applications.

摘要

纳米颗粒是最简单的结构组成部分,因为其直径为纳米级。纳米颗粒通常是原子或分子,当它们集体结合时,会产生小于 100nm 的半径(或直径)。纳米技术的最新发展提供了广泛的方法来研究和监测纳米尺度的各种医学和生物学过程。纳米颗粒可以通过将药物直接输送到癌细胞来帮助诊断和治疗癌症等疾病。它们还可以用于检测体内的疾病生物标志物,有助于提供早期诊断。这些数据很可能对生物学和医学产生积极影响。纳米颗粒可能用于治疗诊断应用和靶向药物输送。这可以显著改善患者的治疗效果,减少诊断和治疗疾病所需的时间、精力和金钱。它还可以减少治疗的副作用,提供更精确和有效的治疗。用于生物医学应用的纳米颗粒包括聚合物和金属纳米颗粒;脂质体和胶束;树枝状大分子和量子点等。在这些纳米颗粒中,金纳米颗粒已成为药物输送应用的有前途的平台。由于其出色的生物相容性、稳定性和可调的物理化学性质,金纳米颗粒非常适合药物输送应用。本综述深入讨论了金纳米颗粒的各种合成方法和药物输送应用。

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