Langman J M, Rowland R, Vernon-Roberts B
Aust J Exp Biol Med Sci. 1985 Oct;63 ( Pt 5):545-53. doi: 10.1038/icb.1985.58.
In guinea pigs deprived of ascorbic acid, the oral administration of degraded E. spinosum carrageenan induced mild to moderate colitis, while E. cottonii consistently induced severe colitis. A variable degree of colitis was observed in scorbutic animals not receiving carrageenan. By contrast, in animals given large daily supplements of ascorbic acid, neither type of carrageenan consistently induced colitis and severe disease was rarely observed. The severe colitis induced by E. cottonii in scorbutic animals markedly affected the mid and distal colon and showed histological changes similar to human ulcerative colitis.
在缺乏抗坏血酸的豚鼠中，口服降解的刺波角叉菜卡拉胶会引发轻度至中度结肠炎，而棉叶麒麟菜则始终会引发严重结肠炎。在未接受卡拉胶的坏血病动物中观察到不同程度的结肠炎。相比之下，在每天大量补充抗坏血酸的动物中，两种类型的卡拉胶都不会始终引发结肠炎，且很少观察到严重疾病。棉叶麒麟菜在坏血病动物中引发的严重结肠炎显著影响结肠中部和远端，并表现出与人类溃疡性结肠炎相似的组织学变化。
