角叉菜胶诱导豚鼠大肠溃疡形成

Gut. 1971 Feb;12(2):164-71. doi: 10.1136/gut.12.2.164.

A 5% aqueous solution of degraded carrageenan derived from the red seaweed Eucheuma spinosum was fed to guinea pigs in their drinking water over a period of 20-45 days. Occult blood in the faeces and multiple ulcers in the caecum, colon and rectum occurred in 100% of animals by the 30th day. The clinical and pathological features bear a close resemblance to human ulcerative colitis. The method provides a simple experimental model for the study of various aspects of the pathology of ulcerative lesions in the large intestine as well as the effects of therapeutic agents.

将源自红藻刺麒麟菜的降解角叉菜胶的5%水溶液，在20至45天的时间里添加到豚鼠的饮用水中喂食。到第30天时，所有动物的粪便中均出现潜血，盲肠、结肠和直肠出现多处溃疡。其临床和病理特征与人类溃疡性结肠炎极为相似。该方法为研究大肠溃疡性病变病理的各个方面以及治疗药物的效果提供了一个简单的实验模型。