Dziwis Jennifer, Dai Xiangfeng, Anderson Chelsea, Kodroff Ellyn, Strobel Mary Jo, Zicarelli Amy, Gray Sarah, Cordell Amanda, Hiremath Girish, Dellon Evan S, Jensen Elizabeth T
Department of Internal Medicine, Gastroenterology Section, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Center for Gastrointestinal Biology and Disease, Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Gastro Hep Adv. 2025 Jun 19;4(10):100732. doi: 10.1016/j.gastha.2025.100732. eCollection 2025.
Extraintestinal symptoms are well-documented in systemic, inflammation-predominant conditions. Less is understood about extragastrointestinal symptoms among individuals with eosinophilic esophagitis (EoE) and non-EoE eosinophilic gastrointestinal diseases (EGIDs). We aimed to describe the differences in the frequency of patient-reported joint or leg pain and headache for EoE and non-EoE EGIDs individuals.
Adult subjects and caregivers of children were recruited via the EGID Partners network and completed the Short-Form McGill Pain Questionnaire and Migraine Disability Assessment Test. T-tests were used to evaluate differences in extraintestinal pain symptomology by EGID type.
We analyzed 95 subjects with EoE only and 24 subjects with non-EoE only EGIDs. Both EoE and non-EoE EGID subjects described frequent leg pain (50% and and 78%, respectively). While no significant difference was observed in number of days of leg pain, pain severity was higher for non-EoE EGID subjects ( < .01). In addition, 78% of EoE only and 89% of non-EoE only EGID subjects reported joint pain, with no significant difference in the number of days of pain, but with higher pain severity for non-EoE EGID subjects ( < .01). Headache disability scores for non-EoE EGID subjects were more severe compared to subjects with EoE alone (17% of non-EoE EGIDs with severe disability vs 9% for EoE; = .01).
Patients with EGIDs may experience extraintestinal symptoms of pain. These symptoms may be more prominent in patients with non-EoE only EGIDs. Understanding of the underlying factors contributing to these symptoms is needed to guide mitigating approaches for these symptoms.
肠外症状在以炎症为主的全身性疾病中已有充分记录。对于嗜酸性食管炎（EoE）和非EoE嗜酸性胃肠道疾病（EGIDs）患者的胃肠道外症状了解较少。我们旨在描述EoE和非EoE EGIDs患者报告的关节或腿部疼痛及头痛频率的差异。
通过EGID伙伴网络招募成年受试者和儿童看护者，并完成简版麦吉尔疼痛问卷和偏头痛残疾评估测试。采用t检验评估不同类型EGID患者肠外疼痛症状的差异。
我们分析了95例仅患有EoE的受试者和24例仅患有非EoE EGIDs的受试者。EoE和非EoE EGIDs受试者均称经常出现腿部疼痛（分别为50%和78%）。虽然腿部疼痛天数无显著差异，但非EoE EGIDs受试者的疼痛严重程度更高（P<0.01）。此外，仅患有EoE的受试者中有78%，仅患有非EoE EGIDs的受试者中有89%报告有关节疼痛，疼痛天数无显著差异，但非EoE EGIDs受试者的疼痛严重程度更高（P<0.01）。与仅患有EoE的受试者相比，非EoE EGIDs受试者的头痛残疾评分更严重（17%的非EoE EGIDs有严重残疾，而EoE为9%；P = 0.01）。
EGIDs患者可能会出现肠外疼痛症状。这些症状在仅患有非EoE EGIDs的患者中可能更为突出。需要了解导致这些症状的潜在因素，以指导缓解这些症状的方法。
