Zhou Wen Bo Sam, Meng JingWen, Zhang Ji
The Alan Edwards Centre for Research on Pain, McGill University, Montreal, QC, Canada.
Faculty of Dentistry, McGill University, Montreal, QC, Canada.
Front Mol Neurosci. 2021 Nov 10;14:785214. doi: 10.3389/fnmol.2021.785214. eCollection 2021.
One of the major clinical manifestations of peripheral neuropathy, either resulting from trauma or diseases, is chronic pain. While it significantly impacts patients' quality of life, the underlying mechanisms remain elusive, and treatment is not satisfactory. Systemic chronic inflammation (SCI) that we are referring to in this perspective is a state of low-grade, persistent, non-infective inflammation, being found in many physiological and pathological conditions. Distinct from acute inflammation, which is a protective process fighting against intruders, SCI might have harmful effects. It has been associated with many chronic non-communicable diseases. We hypothesize that SCI could be a predisposing and/or precipitating factor in the development of chronic pain, as well as associated comorbidities. We reviewed evidence from human clinical studies indicating the coexistence of SCI with various types of chronic pain. We also collated existing data about the sources of SCI and who could have it, showing that those individuals or patients having SCI usually have higher prevalence of chronic pain and psychological comorbidities. We thus elaborate on the need for further research in the connection between SCI and chronic pain. Several hypotheses have been proposed to explain these complex interactions.
外周神经病变（由创伤或疾病引起）的主要临床表现之一是慢性疼痛。虽然它对患者的生活质量有重大影响，但其潜在机制仍然不明，治疗效果也不尽人意。我们在此所指的全身性慢性炎症（SCI）是一种低度、持续性、非感染性的炎症状态，见于许多生理和病理状况。与作为抵御入侵者的保护性过程的急性炎症不同，SCI可能具有有害影响。它与许多慢性非传染性疾病有关。我们假设SCI可能是慢性疼痛以及相关合并症发生发展的一个诱发和/或促发因素。我们回顾了来自人体临床研究的证据，这些证据表明SCI与各种类型的慢性疼痛并存。我们还整理了关于SCI的来源以及哪些人可能患有SCI的现有数据，表明患有SCI的个体或患者通常慢性疼痛和心理合并症的患病率更高。因此，我们阐述了进一步研究SCI与慢性疼痛之间联系的必要性。已经提出了几种假设来解释这些复杂的相互作用。
