Su Xin, Wang Mingqi, Yuan Ruqiang, Guo Lina, Han Yinhe, Huang Chun, Li Ang, Kaplan David L, Wang Xiuli
College of Basic Medical Sciences, Dalian Medical University, Dalian, China 116044.
Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China 116044.
ACS Biomater Sci Eng. 2025 Jun 9;11(6):3165-3181. doi: 10.1021/acsbiomaterials.4c02245. Epub 2025 Apr 18.
With the rapid advancement of biomaterials and tissue engineering technologies, organoid research and its applications have made significant strides. Organoids are increasingly utilized in pharmacology, regenerative medicine, and precision clinical medicine. Current trends in organoid research are moving toward multifunctional composite three-dimensional cultivation and dynamic cultivation strategies. Key technologies driving this evolution, including 3D printing and microfluidics, continue to impact new areas of discovery and clinical relevance. This review provides a systematic overview of these emerging trends, discussing the strengths and limitations of these critical technologies and offering insight and research directions for professionals working in the organoid field.
随着生物材料和组织工程技术的迅速发展，类器官研究及其应用取得了重大进展。类器官在药理学、再生医学和精准临床医学中的应用越来越广泛。目前类器官研究的趋势正朝着多功能复合三维培养和动态培养策略发展。推动这一发展的关键技术，包括3D打印和微流控技术，继续影响着新的发现领域和临床相关性。本综述对这些新兴趋势进行了系统概述，讨论了这些关键技术的优势和局限性，并为类器官领域的专业人士提供了见解和研究方向。
