Treston A M, Hooper W D
Arzneimittelforschung. 1985;35(11):1627-9.
Many therapeutic agents are metabolised along multiple pathways, but up to now there have been few investigations addressing the question of which chemical features of drugs govern the participation in, and quantitative significance of, different biotransformation pathways. To assess the influence of variations of the chemical structure upon metabolism, a series of novel barbiturate analogues has been synthesized. The N1-monoalkylated and N1,N2-dialkylated phenobarbitones and 2-desoxyphenobarbitones have been synthesized via condensation of ethylphenylmalonic acid derivatives with different N-alkylated ureas or thioureas, and/or by base-catalyzed N-alkylation of different barbituric acids.
许多治疗药物会沿着多种途径进行代谢，但到目前为止，很少有研究探讨药物的哪些化学特征决定了其参与不同生物转化途径的情况以及这些途径的定量意义。为了评估化学结构变化对代谢的影响，已合成了一系列新型巴比妥酸盐类似物。通过乙基苯基丙二酸衍生物与不同的N-烷基脲或硫脲缩合，和/或通过不同巴比妥酸的碱催化N-烷基化反应，合成了N1-单烷基化和N1,N2-二烷基化苯巴比妥以及2-脱氧苯巴比妥。
