Wallace Meghan, Mathey Bruce, Yeung Cecilia C S, Appelbaum Jacob S, Wallace Mark
Department of Family Practice, University of Colorado, Denver, Colorado, USA.
Department of Hematology-Oncology, Skagit Regional Health, Mount Vernon, Washington, USA.
Case Rep Hematol. 2025 Aug 28;2025:3390770. doi: 10.1155/crh/3390770. eCollection 2025.
Waldenström macroglobulinemia (WM) and essential thrombocythemia (ET) are distinct hematologic malignancies that have only been reported to co-occur in one previous patient. We present a 64-year-old man with a significant family history for WM who was found to have both ET and WM. He had symptomatic ET, diagnosed by elevated platelets and a positive JAK2 V617F mutation, and asymptomatic WM was found on serum electrophoresis done for screening due to family history. Genomic evaluation of the myeloid and lymphoid cells suggested independent neoplastic transformation. This is the second reported case of a patient with both WM and ET. There was no evidence for a shared mechanism in these dual malignancies.
华氏巨球蛋白血症（WM）和原发性血小板增多症（ET）是不同的血液系统恶性肿瘤，此前仅有1例二者同时出现的报道。我们报告1例64岁男性，有显著的WM家族史，被发现同时患有ET和WM。他有症状性ET，通过血小板升高及JAK2 V617F突变阳性确诊，因家族史进行血清电泳筛查时发现无症状性WM。对髓系和淋巴细胞的基因组评估提示为独立的肿瘤转化。这是第2例报道的同时患有WM和ET的患者。在这两种双重恶性肿瘤中没有共同机制的证据。
