Duggan Jacob J, Petrie Ryan J
Department of Biology, Drexel University, Philadelphia, PA USA.
NPJ Biol Phys Mech. 2025;2(1):21. doi: 10.1038/s44341-025-00027-1. Epub 2025 Sep 3.
While migratory cells can quickly change their mode of migration in complex three-dimensional environments, it is not clear why. Understanding the dynamic and reciprocal relationship migrating cells have with their microenvironments may help reveal why migratory plasticity, or mode-switching, is a common feature of eukaryotic cell motility. In this review, we discuss the physical and mechanical properties of cells and the environments they move through, and how those properties can influence each other. Given the dual role of the cytoskeleton in cell migration and cellular mechanics, we suggest that migratory plasticity derives from the necessity for the cell to maintain mechanical homeostasis in diverse physical environments.
虽然迁移细胞能够在复杂的三维环境中迅速改变其迁移模式，但原因尚不清楚。了解迁移细胞与其微环境之间动态且相互的关系，可能有助于揭示为何迁移可塑性或模式转换是真核细胞运动的一个共同特征。在这篇综述中，我们讨论了细胞及其移动所穿过环境的物理和力学特性，以及这些特性如何相互影响。鉴于细胞骨架在细胞迁移和细胞力学中的双重作用，我们认为迁移可塑性源于细胞在不同物理环境中维持力学稳态的必要性。
