Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland.
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Trends Cell Biol. 2024 Oct;34(10):838-853. doi: 10.1016/j.tcb.2024.02.009. Epub 2024 Mar 27.
Bleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex interactions in blebbing behavior and discuss the generation of force and its transmission during migration. Our analysis aims to deepen the understanding of the physical and molecular mechanisms of bleb-based migration, shedding light on its implications and significance for health and disease.
基于泡囊的迁移是一种保守的细胞运动模式，在生理和病理过程中都起着至关重要的作用。与基于片状伪足的间充质迁移的机制相比，基于泡囊的迁移的动力学仍不太清楚。在这篇综述中，我们系统地强调了前后极性的建立、泡囊的形成和延伸，以及泡囊动力学的不同状态。我们强调了新的证据，提出了质膜-皮质相互作用在泡囊行为中的调节作用，并讨论了在迁移过程中力的产生及其传递。我们的分析旨在深化对基于泡囊的迁移的物理和分子机制的理解，揭示其对健康和疾病的意义和重要性。
