Cushman Daniel M, Johnson Luke A, Burnham Taylor, Nelson Richard, Egbert Jamie, Burnham Robert
Department of Physical Medicine & Rehabilitation University of Utah Salt Lake City Utah USA.
Department of Orthopaedics University of Utah Salt Lake City Utah USA.
J Exp Orthop. 2025 Sep 5;12(3):e70420. doi: 10.1002/jeo2.70420. eCollection 2025 Jul.
To assess the characteristics and effectiveness of low-cost platelet-rich plasma (LC-PRP) for knee osteoarthritis (OA) by evaluating its composition and effect on pain, function, satisfaction, safety and cost-effectiveness.
Level IV evidence single-arm prospective cohort pilot study of 20 subjects (30 knees total) with mild-to-moderate knee OA. Two LC-PRP injections were performed, 3 weeks apart. Platelet extraction/yield, patient-reported outcomes and incidence of adverse events were assessed with a primary endpoint of 6 months. A cost-effectiveness analysis of LC-PRP compared to corticosteroid injection was conducted.
On average, this LC-PRP preparation method allowed for recovery of 85% of platelets. Significant mean differences in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores (total, pain and function) and global assessment score were observed at all follow-up points compared to baseline ( < 0.05 for 1, 3, 6 and 12 months). Satisfaction was noted in 90% of patients at 6 months and 75% of patients at 12 months. No significant adverse events were reported. LC-PRP was less costly ($654 vs. $1308) and yielded more QALYs (0.846 vs. 0.708) than corticosteroid injections. Per injection costs were estimated to be $10 for corticosteroid and $11 for LC-PRP.
This pilot study demonstrates that LC-PRP ($11) may significantly benefit patients with knee OA. LC-PRP appears to be a safe, cost-effective means for improving pain and function in knee OA.
Level IV.
通过评估低成本富血小板血浆（LC-PRP）的成分及其对疼痛、功能、满意度、安全性和成本效益的影响，来评估其用于膝关节骨关节炎（OA）的特性和有效性。
对20名（共30个膝关节）轻至中度膝关节OA患者进行IV级证据单臂前瞻性队列试验研究。进行两次LC-PRP注射，间隔3周。评估血小板提取/产量、患者报告的结局和不良事件发生率，主要终点为6个月。对LC-PRP与皮质类固醇注射进行成本效益分析。
平均而言，这种LC-PRP制备方法可回收85%的血小板。与基线相比，在所有随访点观察到西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分（总分、疼痛和功能）及整体评估评分存在显著平均差异（1、3、6和12个月时P<0.05）。6个月时90%的患者和12个月时75%的患者表示满意。未报告显著不良事件。与皮质类固醇注射相比，LC-PRP成本更低（654美元对1308美元）且产生更多的质量调整生命年（QALY）（0.846对0.708）。估计皮质类固醇每次注射成本为10美元，LC-PRP每次注射成本为11美元。
这项试验研究表明，LC-PRP（11美元）可能使膝关节OA患者显著受益。LC-PRP似乎是改善膝关节OA疼痛和功能的一种安全、具有成本效益的方法。
IV级。
