van Haaren F, De Bruin J P, Heinsbroek R P, Van de Poll N E
Behav Brain Res. 1985 Oct-Nov;18(1):41-9. doi: 10.1016/0166-4328(85)90167-6.
A delayed spatial response alternation procedure was used to assess behavioural differences between male and female Wistar rats, assumed to involve memory functioning. In Expt. I, subjects were required to alternate responses between two levers in an operant environment. The delay between response opportunities was varied between 1, 3, 7.5 and 15 s in different experimental conditions. Incorrect responses produced a time-out from experimental contingencies for the duration of the currently active delay interval. Response accuracy decreased for males as well as females as the duration of the delay interval was increased. Performance improved as subjects were exposed to the different delay interval durations during consecutive trials. Sex differences in behavioural accuracy were not observed. In Expt. II, some subjects who participated in Expt. I received lesions of the medial prefrontal cortex, while others were control-operated. When re-exposed to the 1 and 7.5 s delay conditions of the first experiment, lesioned subjects at first behaved less accurately than control-operated subjects. Accuracy, however, improved after prolonged exposure to the experimental conditions. Sex differences in behaviour after surgery could not be observed.
采用延迟空间反应交替程序来评估假定涉及记忆功能的雄性和雌性Wistar大鼠之间的行为差异。在实验I中，要求实验对象在操作性环境中的两个杠杆之间交替做出反应。在不同的实验条件下，反应机会之间的延迟在1秒、3秒、7.5秒和15秒之间变化。错误反应会导致在当前活跃延迟间隔期间脱离实验意外情况一段时间。随着延迟间隔时间的增加，雄性和雌性的反应准确性均下降。随着实验对象在连续试验中接触不同的延迟间隔时间，表现有所改善。未观察到行为准确性方面的性别差异。在实验II中，一些参与实验I的实验对象接受了内侧前额叶皮质损伤，而其他实验对象则接受了对照手术。当再次暴露于第一个实验的1秒和7.5秒延迟条件时，受损实验对象最初的行为准确性低于接受对照手术的实验对象。然而，在长时间暴露于实验条件后，准确性有所提高。术后行为方面未观察到性别差异。
