Sakurai Y, Sugimoto S
Behav Brain Res. 1985 Oct;17(3):213-9. doi: 10.1016/0166-4328(85)90045-2.
The effect of prefrontal cortex (PFC) and/or dorsomedial thalamus (DMT) lesions on a delayed go/no-go alternation task was studied in the rat. The lesion gave rise to the impairment of smooth alternation of one response to another, resulting in the generation of some successive repetitions of either response. However, either type of response was generated in virtually equal frequencies during pre- and post-surgery sessions. These results suggest that the DMT and PFC are involved in the memory and response control process for generating the alternation response, and they do not mediate either one type of response. Furthermore, DMT or DMT/PFC lesions induced a larger behavioral impairment than PFC lesions indicating that the DMT plays a major role in generating the alternation behavior based on the memory for the previous response.
研究了大鼠前额叶皮层（PFC）和/或背内侧丘脑（DMT）损伤对延迟去/不去交替任务的影响。损伤导致一种反应到另一种反应的平稳交替受损，导致出现一些连续重复的任何一种反应。然而，在手术前和手术后的实验中，两种反应类型的产生频率几乎相等。这些结果表明，DMT和PFC参与了产生交替反应的记忆和反应控制过程，它们并不介导任何一种反应类型。此外，DMT或DMT/PFC损伤比PFC损伤引起更大的行为损伤，表明DMT在基于对先前反应的记忆产生交替行为中起主要作用。
